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Protein Homology Detection Through Alignment of Markov Random Fields: Using MRFalign - Couverture souple

Livre 170 sur 322: SpringerBriefs in Computer Science

Xu, Jinbo

 
9783319149134: Protein Homology Detection Through Alignment of Markov Random Fields: Using MRFalign

Synopsis

This work covers sequence-based protein homology detection, a fundamental and challenging bioinformatics problem with a variety of real-world applications. The text first surveys a few popular homology detection methods, such as Position-Specific Scoring Matrix (PSSM) and Hidden Markov Model (HMM) based methods, and then describes a novel Markov Random Fields (MRF) based method developed by the authors. MRF-based methods are much more sensitive than HMM- and PSSM-based methods for remote homolog detection and fold recognition, as MRFs can model long-range residue-residue interaction. The text also describes the installation, usage and result interpretation of programs implementing the MRF-based method.

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Autres éditions populaires du même titre

9783319149158: Protein Homology Detection Through Alignment of Markov Random Fields: Using MRFalign

Edition présentée

ISBN 10 :  3319149156 ISBN 13 :  9783319149158
Editeur : Springer, 2015
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