Regulation of Membrane Na+-k+ Atpase - Couverture rigide

Couverture rigide

ISBN 10 : 3319247484 ISBN 13 : 9783319247489

Editeur : Springer International Publishing AG, 2015

Synopsis

Na⁺-K⁺ ATPase or Na-pump ATPase, a member of "P"-type ATPase superfamily, is characterized by association of multiple isoforms mainly of it's α- and β- subunits. At present four different α- (α-1,α-2,α-3 and α-4) and three β- (β-1, β-2, and β-3) isoforms have been identified in mammalian cells and their differential expressions are tissue specific. Regulation of Na⁺-K⁺ ATPase activity is an important but a complex process, which involves short-term and long-term mechanisms. Short-term regulation of Na⁺-K⁺ ATPase is either mediated by changes in intracellular Na⁺ concentrations that directly affect the Na⁺-pump activity or by phosphorylation/dephosphorylation-mediated by some stimulants leading to changes in its expression and transport properties. On the other hand, long-term regulation of Na⁺-K⁺ ATPase is mediated by hormones, such as mineralocorticoids and thyroid hormones, which cause changes in the transcription of genes of α- and β- subunits leading to an increased expression in the level of Na⁺-pump. Several studies have revealed a relatively new type of regulation that involves the association of small, single span membrane proteins with this enzyme. These proteins belong to the FXYD family, the members of which share a common signature sequence encompassing the transmembra

ne domain adjacent to the isoform(s) of α-β subunits of Na⁺-K⁺ ATPase. Considering the extraordinary importance of Na⁺-K⁺ ATPase in cellular function, several internationally established investigators have contributed their articles in the monograph entitled "Regulation of Membrane Na⁺-K⁺ ATPase" for inspiring young scientists and graduate students to enrich their knowledge on the enzyme, and we are sure that this book will soon be considered as a comprehensive scientific literature in the area of Na⁺-K⁺ ATPase regulation in health and disease.

Détails de l'édition

• Éditeur: Springer International Publishing AG
• Date d'édition: 2015
• Langue: anglais
• ISBN 10: 3319247484
• ISBN 13: 9783319247489
• Reliure: Relié
• Numéro d'édition: 1
• Nombre de pages: 447
• Éditeur: Chakraborti Sajal, Dhalla Naranjan S
• Coordonnées du fabricant: Springer Nature Customer Service Center GmbH; ProductSafety@springernature.com; ; Europaplatz 3; Heidelberg; 69115; Allemagne