Synopsis
Arrestins: discovery of the family and functional role of conformational flexibility.- Overview of arrestin-mediated signaling with receptors and non-receptor binding partners.- Initial crystallographic studies of visual arrestin: insights and perspectives.- Structural basis for b-arrestins in GPCR trafficking.- Arrestin-3: the structural basis of lower receptor selectivity.- Phosphate sensor and construction of phosphorylation-independent arrestins.- Comprehensive analysis of the role of arrestin residues in receptor binding.- How arrestin recognizes and binds active GPCRs.- Localization of conformational dynamics of arrestins by HDX-MS.- GPCR footprint on arrestins and manipulation of receptor specificity.- The structure of the polar core mutant R175E and its functional implications.- Active conformations of arrestins: expected and unexpected changes.- The arrestin-receptor complex: exciting answers and new questions.- Scaffolding c-Jun N-terminal kinase cascades: mechanistic insights from the reconstituted arrestin-JNK cascades.- Arrestin-dependent ERK activation and its disruption.- The functional role of the conformational changes in arrestin upon activation.- Is signaling specificity encoded in arrestin conformation?.- Monofunctional elements of multi-functional arrestin proteins.- Arrestins in cell death.
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