Articles liés à CFTR and Cystic Fibrosis: From Structure to Function
Synopsis
Discusses the relationship between the CFTR protein and cystic fibrosis
Explains how the protein structure and structure-defects affect the function of CFTR
Presents CFTR-based and independent therapies to correct the basic defect
Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.
À propos de l?auteur
Carlos M Farinha obtained his Ph.D. (2003) and Habilitation (2015) in Biochemistry from the University of Lisbon. He has worked at the National Institute of Health Dr. Ricardo Jorge and at the Faculty of Sciences, University of Lisbon with training periods at the Johns Hopkins University School of Medicine, Baltimore, MD, USA and at the University of Pittsburgh School of Medicine - Children's Hospital of Pittsburgh, Pittsburgh, PA, USA. Currently, he is Assistant Professor with habilitation at the Faculty of Sciences, University of Lisbon, and Principal Investigator at BioISI - Biosystems and Integrative Sciences Institute. His research focuses on the molecular mechanisms of cystic fibrosis (CF), in particular the endoplasmic reticulum retention and early degradation of CFTR's most common mutant and characterization of the role of CFTR interacting proteins. He received the 2012 ERS Romain Pauwels Research Award from the European Respiratory Society for "research into the different aspects of CFTR biology".
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CFTR and Cystic Fibrosis
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Springer International Publishing, 2017
ISBN 10 : 3319654934
ISBN 13 : 9783319654935
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Etat : New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Carlos M Farinha obtained his Ph.D. (2003) and Habilitation (2015) in Biochemistry from the University of Lisbon. He has worked at the National Institute of Health Dr. Ricardo Jorge and at the Faculty of Sciences, University of Lisbon with training perio. N° de réf. du vendeur 154279885
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CFTR and Cystic Fibrosis: From Structure to Function (SpringerBriefs in Molecular Science)
Vendeur : Ria Christie Collections, Uxbridge, Royaume-Uni
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CFTR and Cystic Fibrosis
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Berlin Springer International Publishing Springer Okt 2017, 2017
ISBN 10 : 3319654934
ISBN 13 : 9783319654935
Neuf
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Vendeur : BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Allemagne
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Taschenbuch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This Brief is devoted to the CFTR protein and cystic fibrosis, and it provides an updated perspective of the genetic, functional and cellular processes involved in this conformational disorder. Starting with a historical perspective on cystic fibrosis and its clinical features, the author departs into an in-depth description of the biology of the CFTR protein, ending with a discussion on the latest approaches aimed at developing corrective therapies for cystic fibrosis.First the basic aspects of cystic fibrosis as a disorder are addressed, focusing on genetics and mutation prevalence. Then the CFTR protein is discussed in detail: its structure and classification within the ABC transporter superfamily, its biogenesis with membrane insertion and chaperone assisted folding, its glycosylation and how it regulates the endoplasmatic reticulum quality control mechanisms that assess CFTR folding status. Extra attention is given to post-ER trafficking and regulation of membrane stability and anchoring, and to CFTR functions. This is linked to the molecular mechanisms through which different CFTR mutations cause cystic fibrosis. Finally, the different efforts aiming at rescuing the basic defect, most of which aim at repairing CFTR dysfunction, are covered. Through this integrated perspective, readers will obtain a unique insight into this fascinating membrane-bound protein and its associated disease. This Brief appeals to an audience interested in human genetics, protein folding, protein trafficking and physiology. 56 pp. Englisch. N° de réf. du vendeur 9783319654935
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CFTR and Cystic Fibrosis : From Structure to Function
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Springer, Berlin, Springer International Publishing, Springer, 2017
ISBN 10 : 3319654934
ISBN 13 : 9783319654935
Neuf
Taschenbuch
Vendeur : AHA-BUCH GmbH, Einbeck, Allemagne
Évaluation du vendeur 5 sur 5 étoiles
Taschenbuch. Etat : Neu. Druck auf Anfrage Neuware - Printed after ordering - This Brief is devoted to the CFTR protein and cystic fibrosis, and it provides an updated perspective of the genetic, functional and cellular processes involved in this conformational disorder. Starting with a historical perspective on cystic fibrosis and its clinical features, the author departs into an in-depth description of the biology of the CFTR protein, ending with a discussion on the latest approaches aimed at developing corrective therapies for cystic fibrosis.First the basic aspects of cystic fibrosis as a disorder are addressed, focusing on genetics and mutation prevalence. Then the CFTR protein is discussed in detail: its structure and classification within the ABC transporter superfamily, its biogenesis with membrane insertion and chaperone assisted folding, its glycosylation and how it regulates the endoplasmatic reticulum quality control mechanisms that assess CFTR folding status. Extra attention is given to post-ER trafficking and regulation of membrane stability and anchoring, and to CFTR functions. This is linked to the molecular mechanisms through which different CFTR mutations cause cystic fibrosis. Finally, the different efforts aiming at rescuing the basic defect, most of which aim at repairing CFTR dysfunction, are covered. Through this integrated perspective, readers will obtain a unique insight into this fascinating membrane-bound protein and its associated disease. This Brief appeals to an audience interested in human genetics, protein folding, protein trafficking and physiology. N° de réf. du vendeur 9783319654935
Quantité disponible : 2 disponible(s)
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CFTR and Cystic Fibrosis: From Structure to Function (SpringerBriefs in Molecular Science)
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Paperback. Etat : New. N° de réf. du vendeur 6666-IUK-9783319654935
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Cftr and Cystic Fibrosis : From Structure to Function
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CFTR and Cystic Fibrosis: From Structure to Function (SpringerBriefs in Molecular Science)
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Cftr and Cystic Fibrosis : From Structure to Function
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Cftr and Cystic Fibrosis : From Structure to Function
Edité par
Springer, 2017
ISBN 10 : 3319654934
ISBN 13 : 9783319654935
Ancien ou d'occasion
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Vendeur : GreatBookPrices, Columbia, MD, Etats-Unis
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Etat : As New. Unread book in perfect condition. N° de réf. du vendeur 29773541
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Cftr and Cystic Fibrosis : From Structure to Function
Edité par
Springer, 2017
ISBN 10 : 3319654934
ISBN 13 : 9783319654935
Ancien ou d'occasion
Couverture souple
Vendeur : GreatBookPricesUK, Woodford Green, Royaume-Uni
Évaluation du vendeur 5 sur 5 étoiles
Etat : As New. Unread book in perfect condition. N° de réf. du vendeur 29773541
Quantité disponible : Plus de 20 disponibles