Computing Characterizations of Drugs for Ion Channels and Receptors Using Markov Models - Couverture souple

Livre 83 sur 111: Lecture Notes in Computational Science and Engineering

Tveito, Aslak ; Lines, Glenn T.

9783319807089: Computing Characterizations of Drugs for Ion Channels and Receptors Using Markov Models

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ISBN 10 : 3319807080 ISBN 13 : 9783319807089

Editeur : Springer, 2018

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Flow of ions through voltage gated channels can be represented theoretically using stochastic differential equations where the gating mechanism is represented by a Markov model. The flow through a channel can be manipulated using various drugs, and the effect of a given drug can be reflected by changing the Markov model. These lecture notes provide an accessible introduction to the mathematical methods needed to deal with these models. They emphasize the use of numerical methods and provide sufficient details for the reader to implement the models and thereby study the effect of various drugs. Examples in the text include stochastic calcium release from internal storage systems in cells, as well as stochastic models of the transmembrane potential. Well known Markov models are studied and a systematic approach to including the effect of mutations is presented. Lastly, the book shows how to derive the optimal properties of a theoretical model of a drug for a given mutation defined in terms of a Markov model.

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�diteur: Springer
Date d'�dition: 2018
Langue: anglais
ISBN 10: 3319807080
ISBN 13: 9783319807089
Reliure: Broch�
Nombre de pages: 288
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Computing Characterizations of Drugs for Ion Channels and Receptors Using Markov Models (Lecture Notes in Computational Science and Engineering, 111)

Tveito, Aslak; Lines, Glenn T.

Edit� par Springer, 2018

ISBN 10 : 3319807080 ISBN 13 : 9783319807089

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Tveito:Computing Characterizations of D (eng)

Tveito, Aslak

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ISBN 10 : 3319807080 ISBN 13 : 9783319807089

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Computing Characterizations of Drugs for Ion Channels and Receptors Using Markov Models

Glenn T. Lines

Edit� par Springer International Publishing Apr 2018, 2018

ISBN 10 : 3319807080 ISBN 13 : 9783319807089

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Taschenbuch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Flow of ions through voltage gatedchannels can be represented theoretically using stochastic differentialequations where the gating mechanism is represented by a Markov model. The flow through achannel can be manipulated using various drugs, and the effect of a given drugcan be reflected bychanging the Markov model. These lecture notes provide an accessibleintroduction to the mathematical methods needed to deal with these models. They emphasize the use ofnumerical methods and provide sufficient details for the reader to implementthe models and thereby study the effect of various drugs. Examples in thetext include stochastic calcium release from internal storage systems in cells,as well as stochasticmodels of the transmembrane potential. Well known Markov models are studied anda systematic approach toincluding the effect of mutations is presented. Lastly, the book shows how to derive the optimal propertiesof a theoretical model of a drug for a given mutation defined in termsof a Markov model. 288 pp. Englisch. N� de r�f. du vendeur 9783319807089

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Computing Characterizations of Drugs for Ion Channels and Receptors Using Markov Models

Aslak Tveito|Glenn T. Lines

Edit� par Springer International Publishing, 2018

ISBN 10 : 3319807080 ISBN 13 : 9783319807089

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Etat : New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Offers an accessible introduction to an important theory in a field ofgrowing relevanceIncludes completedetails of models and methods, enabling the reader to implement and study themodels under considerationPursues a systematicappro. N� de r�f. du vendeur 448755742

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Computing Characterizations of Drugs for Ion Channels and Receptors Using Markov Models

Aslak Tveito

Edit� par Springer, Palgrave Macmillan Apr 2018, 2018

ISBN 10 : 3319807080 ISBN 13 : 9783319807089

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Vendeur : buchversandmimpf2000, Emtmannsberg, BAYE, Allemagne

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Taschenbuch. Etat : Neu. This item is printed on demand - Print on Demand Titel. Neuware -Flow of ions through voltage gatedchannels can be represented theoretically using stochastic differentialequations where the gating mechanism is represented by a Markov model. The flow through achannel can be manipulated using various drugs, and the effect of a given drugcan be reflected bychanging the Markov model. These lecture notes provide an accessibleintroduction to the mathematical methods needed to deal with these models. They emphasize the use ofnumerical methods and provide sufficient details for the reader to implementthe models and thereby study the effect of various drugs. Examples in thetext include stochastic calcium release from internal storage systems in cellsas well as stochasticmodels of the transmembrane potential. Well known Markov models are studied anda systematic approach toincluding the effect of mutations is presented. Lastly, the book shows how to derive the optimal propertiesof a theoretical model of a drug for a given mutation defined in termsof a Markov model.Springer-Verlag KG, Sachsenplatz 4-6, 1201 Wien 288 pp. Englisch. N� de r�f. du vendeur 9783319807089

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Computing Characterizations of Drugs for Ion Channels and Receptors Using Markov Models

Glenn T. Lines

Edit� par Springer International Publishing, Springer International Publishing, 2018

ISBN 10 : 3319807080 ISBN 13 : 9783319807089

Neuf Taschenbuch

Vendeur : AHA-BUCH GmbH, Einbeck, Allemagne

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Taschenbuch. Etat : Neu. Druck auf Anfrage Neuware - Printed after ordering - Flow of ions through voltage gatedchannels can be represented theoretically using stochastic differentialequations where the gating mechanism is represented by a Markov model. The flow through achannel can be manipulated using various drugs, and the effect of a given drugcan be reflected bychanging the Markov model. These lecture notes provide an accessibleintroduction to the mathematical methods needed to deal with these models. They emphasize the use ofnumerical methods and provide sufficient details for the reader to implementthe models and thereby study the effect of various drugs. Examples in thetext include stochastic calcium release from internal storage systems in cells,as well as stochasticmodels of the transmembrane potential. Well known Markov models are studied anda systematic approach toincluding the effect of mutations is presented. Lastly, the book shows how to derive the optimal propertiesof a theoretical model of a drug for a given mutation defined in termsof a Markov model. N� de r�f. du vendeur 9783319807089

Contacter le vendeur