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9783319952277: Predictive Biomarkers in Oncology: Applications in Precision Medicine

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ISBN 10 : 3319952277 ISBN 13 : 9783319952277

Editeur : Springer International Publishing AG, 2018

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Predictive Biomarkers in Oncology: Applications in Precision Medicine

Les informations fournies dans la section � Synopsis � peuvent faire r�f�rence � une autre �dition de ce titre.

� propos de l?auteur

Sunil Badve
Indiana University School of Medicine
Indianapolis, IN
USA George Kumar
Targos Inc.
Issaquah, WA
USA

Les informations fournies dans la section � A propos du livre � peuvent faire r�f�rence � une autre �dition de ce titre.

�diteur: Springer International Publishing AG
Date d'�dition: 2018
Langue: anglais
ISBN 10: 3319952277
ISBN 13: 9783319952277
Reliure: Reli�
Nombre de pages: 663
�diteur: Badve Sunil, Kumar George Louis
Coordonn�es du fabricant: ProductSafety@springernature.com
ProductSafety@springernature.com

Poststr. 9
Darmstadt
64293
Allemagne

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Predictive Biomarkers in Oncology (eng)

Badve, Sunil

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ISBN 10 : 3319952277 ISBN 13 : 9783319952277

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PREDICTIVE BIOMARKERS IN ONCOLOGY APPLICATIONS IN PRECISION MEDICINE (HB 2019)

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ISBN 10 : 3319952277 ISBN 13 : 9783319952277

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Predictive Biomarkers in Oncology

Badve, Sunil|Kumar, George Louis

Edit� par Springer International Publishing, 2018

ISBN 10 : 3319952277 ISBN 13 : 9783319952277

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Gebunden. Etat : New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. The &nbspfirst single source on this subject to put all this evidence together in a concise and easy to understand manner.Uniquely formatted with sidebars, special interest boxes and illustrations.Provides . N� de r�f. du vendeur 230746446

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PREDICTIVE BIOMARKERS IN ONCOLOGY APPLICATIONS IN PRECISION MEDICINE (HB 2019)

Edit� par Springer, 2018

ISBN 10 : 3319952277 ISBN 13 : 9783319952277

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Predictive Biomarkers in Oncology

George Louis Kumar

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ISBN 10 : 3319952277 ISBN 13 : 9783319952277

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Buch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -'Precision/personalized or stratified medicine' refers to the tailoring of medical treatment or drug administration to the individual characteristics of each patient treatment. It does not literally mean that a pharmaceutical company makes a drug for an individual patient for consumption and treatment but rather means the ability to stratify (or classify) individuals into sub-populations that differ in their responsiveness to a specific drug. A marker that provides information on the likely response to therapy, i.e., either in terms of tumor shrinkage or survival of the patient is termed 'predictive biomarker'. Despite their promise in precision medicine and the explosion of knowledge in this area, there is not a single source on this subject that puts all this evidence together in a concise or richly illustrated and easy to understand manner. This book provides a collection of ingeniously organized, well-illustrated and up-to-date authoritative chapters divided into five sections that are clear and easy to understand. Section one provides an overview of biomarkers, introduces the basic terminologies, definitions, technologies, tools and concepts associated with this subject in the form of illustrations/graphics, photographs and concise texts. Several recent biomarker endeavors that have been initiated and funded by the National Cancer Institute, National Institutes of Health, FDA and other International organizations are presented. Section two involves the signaling pathways controlling cell growth and differentiation altered in cancer. This section analyzes how predictive biomarkers are altered (expressed or amplified) across cancer types. Section three explores how predictive biomarkers play a role in patient stratification and tailored treatment in relationship to specific cancers. In addition, it includes discussion on the various precision medicine initiatives that are going on across the globe (e.g. TARGET, NCI-MATCH, BATTLE, SHIVA, etc.). Section four discusses: (a) how pharmaceutical companies validate predictive biomarker assays and accompanying companion diagnostics either internally or externally with partner companies such as central laboratories or clinical research organizations, and (b) how predictive biomarker tests fall under the oversight of US FDA, Centers for Medicare & Medicaid Services (CMS) and state laws. Section five wraps up novel agents and targets that are being used as targets for cancer therapeutics. The biomarkers associated with these protocols will also be presented. Throughout the book, sidebars, special interest boxes and illustrations are used to explain terms that are either newly introduced, uncommon, or specialized. Predictive Biomarkers in Oncology will serve as a definitive guide for practicing pathologists, oncologists, basic researchers, and personnel in the pharmaceutical or diagnostic industry interested in learning how 'predictive biomarkers' are used in precision cancer therapy. 664 pp. Englisch. N� de r�f. du vendeur 9783319952277

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Predictive Biomarkers in Oncology | Applications in Precision Medicine

Sunil Badve (u. a.)

Edit� par Springer, 2018

ISBN 10 : 3319952277 ISBN 13 : 9783319952277

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Predictive Biomarkers in Oncology

Sunil Badve

Edit� par Springer, Springer Dez 2018, 2018

ISBN 10 : 3319952277 ISBN 13 : 9783319952277

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Buch. Etat : Neu. This item is printed on demand - Print on Demand Titel. Neuware -'Precision/personalized or stratified medicine' refers to the tailoring of medical treatment or drug administration to the individual characteristics of each patient treatment. It does not literally mean that a pharmaceutical company makes a drug for an individual patient for consumption and treatment but rather means the ability to stratify (or classify) individuals into sub-populations that differ in their responsiveness to a specific drug. A marker that provides information on the likely response to therapy, i.e., either in terms of tumor shrinkage or survival of the patient is termed 'predictive biomarker'. Despite their promise in precision medicine and the explosion of knowledge in this area, there is not a single source on this subject that puts all this evidence together in a concise or richly illustrated and easy to understand manner.Springer-Verlag KG, Sachsenplatz 4-6, 1201 Wien 664 pp. Englisch. N� de r�f. du vendeur 9783319952277

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Predictive Biomarkers in Oncology : Applications in Precision Medicine

Sunil Badve

Edit� par Springer, Springer, 2018

ISBN 10 : 3319952277 ISBN 13 : 9783319952277

Neuf Couverture rigide

Vendeur : AHA-BUCH GmbH, Einbeck, Allemagne

�valuation du vendeur 5 sur 5 �toiles

Buch. Etat : Neu. Druck auf Anfrage Neuware - Printed after ordering - 'Precision/personalized or stratified medicine' refers to the tailoring of medical treatment or drug administration to the individual characteristics of each patient treatment. It does not literally mean that a pharmaceutical company makes a drug for an individual patient for consumption and treatment but rather means the ability to stratify (or classify) individuals into sub-populations that differ in their responsiveness to a specific drug. A marker that provides information on the likely response to therapy, i.e., either in terms of tumor shrinkage or survival of the patient is termed 'predictive biomarker'. Despite their promise in precision medicine and the explosion of knowledge in this area, there is not a single source on this subject that puts all this evidence together in a concise or richly illustrated and easy to understand manner. This book provides a collection of ingeniously organized, well-illustrated and up-to-date authoritative chapters divided into five sections that are clear and easy to understand. Section one provides an overview of biomarkers, introduces the basic terminologies, definitions, technologies, tools and concepts associated with this subject in the form of illustrations/graphics, photographs and concise texts. Several recent biomarker endeavors that have been initiated and funded by the National Cancer Institute, National Institutes of Health, FDA and other International organizations are presented. Section two involves the signaling pathways controlling cell growth and differentiation altered in cancer. This section analyzes how predictive biomarkers are altered (expressed or amplified) across cancer types. Section three explores how predictive biomarkers play a role in patient stratification and tailored treatment in relationship to specific cancers. In addition, it includes discussion on the various precision medicine initiatives that are going on across the globe (e.g. TARGET, NCI-MATCH, BATTLE, SHIVA, etc.). Section four discusses: (a) how pharmaceutical companies validate predictive biomarker assays and accompanying companion diagnostics either internally or externally with partner companies such as central laboratories or clinical research organizations, and (b) how predictive biomarker tests fall under the oversight of US FDA, Centers for Medicare & Medicaid Services (CMS) and state laws. Section five wraps up novel agents and targets that are being used as targets for cancer therapeutics. The biomarkers associated with these protocols will also be presented. Throughout the book, sidebars, special interest boxes and illustrations are used to explain terms that are either newly introduced, uncommon, or specialized. Predictive Biomarkers in Oncology will serve as a definitive guide for practicing pathologists, oncologists, basic researchers, and personnel in the pharmaceutical or diagnostic industry interested in learning how 'predictive biomarkers' are used in precision cancer therapy. N� de r�f. du vendeur 9783319952277

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