Characterization of Peroxynitrite modified Glycated DNA - Couverture souple

Ahmad, Rizwan; Islam, Wani Adil; Mushtaq, Shaheena

 
9783330014213: Characterization of Peroxynitrite modified Glycated DNA
Couverture souple
ISBN 10 : 3330014210 ISBN 13 : 9783330014213
Editeur : LAP LAMBERT Academic Publishing, 2016

Synopsis

Glycation is the non-enzymatic addition or insertion of sugar molecules into DNA, protein and lipids that occur in biological molecules. The glycation of DNA give rise to characteristic nucleotide adducts, some of which have been found to increase in oxidative stress . The glycation causes damage to DNA which is associated with mutagenesis, carcinogenesis and is also considered to be a pathogenic factor for Diabetes mellitus. Improved understanding of DNA glycation may give guidance on decreasing the risk of tumor associated with dietary factors.Peroxynitrite is a potent initiator of DNA strand breakage which is an obligatory stimulus for activation of nuclear enzyme, poly-ADP ribosyl synthase or polymerase (PARP) excess activation of PARP can kill cell by depleting NAD+ and energy production, and this may be one of the mechanism by which cells with excess DNA damage are eliminated ( which undergoes necrosis or apoptosis).

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Présentation de l'éditeur

Glycation is the non-enzymatic addition or insertion of sugar molecules into DNA, protein and lipids that occur in biological molecules. The glycation of DNA give rise to characteristic nucleotide adducts, some of which have been found to increase in oxidative stress . The glycation causes damage to DNA which is associated with mutagenesis, carcinogenesis and is also considered to be a pathogenic factor for Diabetes mellitus. Improved understanding of DNA glycation may give guidance on decreasing the risk of tumor associated with dietary factors.Peroxynitrite is a potent initiator of DNA strand breakage which is an obligatory stimulus for activation of nuclear enzyme, poly-ADP ribosyl synthase or polymerase (PARP) excess activation of PARP can kill cell by depleting NAD+ and energy production, and this may be one of the mechanism by which cells with excess DNA damage are eliminated ( which undergoes necrosis or apoptosis).

Biographie de l'auteur

Dr. Rizwan Ahmad is working as Dean Academics and Head,Biochemistry Department, Uttaranchal (PG) College of Biomedical Sciences and Hospital, Dehradun, India. Dr. Ahmad did his M.Phil. and Ph.D. in Biochemistry from Faculty of Medicine, Jawaharlal Nehru Medical College, A.M.U., Aligarh,India.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2016
Langue
anglais
ISBN 10 
3330014210
ISBN 13 
9783330014213
Reliure
Broché
Nombre de pages
68
Coordonnées du fabricant
non disponible
Personne responsable
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