The Concept of Endocannabinoid Signaling System in Cancer: An Emerging Target of Pharmacotherapy - Couverture souple

Fatima, Talath; Azeez, Syed Abdul

 
9783330026490: The Concept of Endocannabinoid Signaling System in Cancer: An Emerging Target of Pharmacotherapy
Couverture souple
ISBN 10 : 3330026499 ISBN 13 : 9783330026490
Editeur : LAP LAMBERT Academic Publishing, 2016

Synopsis

Endogenous arachidonic acid metabolites with properties similar to compounds of Cannabis sativa Linnaeus, the so-called Endocannabinoids, have effects on various types of cancer. The main active ingredient of cannabis, Δ9-tetrahydrocannabinol (Δ9-THC), produces its effects through activation of CB1 and CB2 receptors. CB1 receptors are expressed at high levels in the central nervous system (CNS), whereas CB2 receptors are concentrated predominantly, although not exclusively, in cells of the immune system. Although endocannabinoids and synthetic cannabinoids may have pro-proliferative effects, predominantly inhibitory effects on tumor growth, angiogenesis, migration and metastasis have been described. Exceptionally, these effects may be selective for the cancer cells, while normal cells and tissues are spared. Such apparent tumor cell selectivity makes the endocannabinoid system an attractive potential target for cancer therapy. Further basic research on anti-cancer properties of cannabinoids as well as clinical trials of cannabinoid therapeutic efficacy in breast, prostate and bone cancer is therefore warranted.

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Présentation de l'éditeur

Endogenous arachidonic acid metabolites with properties similar to compounds of Cannabis sativa Linnaeus, the so-called Endocannabinoids, have effects on various types of cancer. The main active ingredient of cannabis, Δ9-tetrahydrocannabinol (Δ9-THC), produces its effects through activation of CB1 and CB2 receptors. CB1 receptors are expressed at high levels in the central nervous system (CNS), whereas CB2 receptors are concentrated predominantly, although not exclusively, in cells of the immune system. Although endocannabinoids and synthetic cannabinoids may have pro-proliferative effects, predominantly inhibitory effects on tumor growth, angiogenesis, migration and metastasis have been described. Exceptionally, these effects may be selective for the cancer cells, while normal cells and tissues are spared. Such apparent tumor cell selectivity makes the endocannabinoid system an attractive potential target for cancer therapy. Further basic research on anti-cancer properties of cannabinoids as well as clinical trials of cannabinoid therapeutic efficacy in breast, prostate and bone cancer is therefore warranted.

Biographie de l'auteur

Talath Fatima is a Pharmacy Student at Deccan School of Pharmacy, Hyderabad. She has 15 Scientific Publications to her Credit.She serves as one of the youngest Editorial Board Members of three Pharmaceutical Journals.Dr.Syed Abdul Azeez is Academician, Scientist & Administrator served in Public/Private Organisations having 60 publications to credit

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2016
Langue
anglais
ISBN 10 
3330026499
ISBN 13 
9783330026490
Reliure
Broché
Nombre de pages
80
Coordonnées du fabricant
non disponible
Personne responsable
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