Formulation and Evaluation of Pantoprazole Sodium EC Tablets: Pantoprazole Sodium Delayed Release Tablets - Couverture souple

Unnisa Begum, Rahmath

 
9783330038776: Formulation and Evaluation of Pantoprazole Sodium EC Tablets: Pantoprazole Sodium Delayed Release Tablets
Couverture souple
ISBN 10 : 3330038772 ISBN 13 : 9783330038776
Editeur : LAP LAMBERT Academic Publishing, 2017

Synopsis

Pantoprazole is a PPI acts by suppressing an acid secretion by inhibiting the H+ K+ ATPase belongs to group of benzimidazole.In aqueous media of pH below 4 it suffers a practically complete decomposition within a period shorter than 10 minutes.It has an irritant effect on the stomach can be coated with a substance that will only dissolve in the small intestine,EC added to the formulation delivering to a basic pH environment.The prepared tablets using 3 different superdisintegrants in different ratio’s were evaluated for hardness,thickness,weight variation, friability, disintegration, dissolution& drug content uniformity and the results were found to comply with official standards an optimised formulation was selected and coated using enteric coating polymers such as Eudragit L100,PVAP& Eudragit RS100 by the spray coating method.The in vitro release was studied using pH 1.2 acidic buffer and pH 6.8 phosphate buffer and the study revealed that the prepared tablets were able to release the drug in an intestine,from the Prepared all batch’s EC8 was found to be best showed the drug release of 100.16% within 2hrs 45min,with acid resistance time of about 2hrs.stability studies was also done.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

À propos de l'auteur

My first salutation goes to the Almighty Allah and my dear parents for being ever so kind & courteous to me. I cannot forget the timely co-operation given by my brothers, sisters & friends.I had completed my b.pharmacy from RBVRR womens college of pharmacy in 2014 & m.pharmacy from deccan school of pharmacy in 2016.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2017
Langue
anglais
ISBN 10 
3330038772
ISBN 13 
9783330038776
Reliure
Broché
Nombre de pages
180
Coordonnées du fabricant
non disponible
Personne responsable
KreGa Onlinehandel GmbH
4950000000000
info@krega-onlinehandel.de

Birkenweg 31
Brakel
33034
Allemagne