Antibiogram & Detection of ESBL & MBL in Gram-Negative Bacteria - Couverture souple

Ejikeugwu, Chika; Esimone, Charles; Adikwu, Michael

 
9783330318892: Antibiogram & Detection of ESBL & MBL in Gram-Negative Bacteria
Couverture souple
ISBN 10 : 3330318899 ISBN 13 : 9783330318892
Editeur : LAP LAMBERT Academic Publishing, 2017

Synopsis

The emergence of new beta-lactamases such as extended spectrum β-lactamase (ESBL) and metallo β-lactamase (MBL) is an important mechanism by which pathogenic bacteria develop resistance to beta-lactams. This is of global concern as they are known to make the treatment of bacterial related infections difficult. The objective of this research was to determine phenotypically the occurrence of ESBL and MBL-producing Gram-negative bacteria from clinical isolates. ESBL was detected in 7.5 % Escherichia coli and 33.3 % Klebsiella pneumoniae. None of the P. aeruginosa isolates in our study showed ESBL production by the double disk synergy test (DDST) method. Disk potentiation test detected MBL in 12.5 % E. coli, 15.4 % Klebsiella pneumoniae and 10 % P. aeruginosa isolates while modified Hodges test also detected MBL in 12.5 % Escherichia coli, 7.7 % Klebsiella pneumoniae and 15 % Pseudomonas aeruginosa isolates. Our study reveals that Gram-negative bacteria of clinical origin produce ESBL and MBL. ESBL and MBL detection is crucial as this will help physicians to prescribe the proper therapy for affected patients. Rational use of antibiotics is vital to control resistant microbes.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Présentation de l'éditeur

The emergence of new beta-lactamases such as extended spectrum β-lactamase (ESBL) and metallo β-lactamase (MBL) is an important mechanism by which pathogenic bacteria develop resistance to beta-lactams. This is of global concern as they are known to make the treatment of bacterial related infections difficult. The objective of this research was to determine phenotypically the occurrence of ESBL and MBL-producing Gram-negative bacteria from clinical isolates. ESBL was detected in 7.5 % Escherichia coli and 33.3 % Klebsiella pneumoniae. None of the P. aeruginosa isolates in our study showed ESBL production by the double disk synergy test (DDST) method. Disk potentiation test detected MBL in 12.5 % E. coli, 15.4 % Klebsiella pneumoniae and 10 % P. aeruginosa isolates while modified Hodges test also detected MBL in 12.5 % Escherichia coli, 7.7 % Klebsiella pneumoniae and 15 % Pseudomonas aeruginosa isolates. Our study reveals that Gram-negative bacteria of clinical origin produce ESBL and MBL. ESBL and MBL detection is crucial as this will help physicians to prescribe the proper therapy for affected patients. Rational use of antibiotics is vital to control resistant microbes.

Biographie de l'auteur

Dr. Ejikeugwu E.P. Chika (Ph.D) is a lecturer in Applied Microbiology Department, Ebonyi State University, Abakaliki, Nigeria. He owns MicroDok, an online website (www.microdok.com) that delivers microbiology notes and related services to students around the globe. He is a passionate Development Knowledge Facilitator (DKF), Trainer & Drummer.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2017
Langue
anglais
ISBN 10 
3330318899
ISBN 13 
9783330318892
Reliure
Broché
Nombre de pages
164
Coordonnées du fabricant
non disponible
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