Spatial Pattern of Transcription Factor Binding Sites in genome - Couverture souple

Verma, Divya

Couverture souple

ISBN 10 : 3330345845 ISBN 13 : 9783330345843

Editeur : LAP LAMBERT Academic Publishing, 2017

Synopsis

A mammalian body consists of more than 200 types of cells; almost all of them having the same genome but different morphology and functions. These differences are due to cell-specific gene regulatory machinery. Mammalian genome has a complex organisation of regulatory sequences associated with different regulatory elements. The linear DNA in the nucleus is folded in a very complex manner and this folding brings distantly placed regions closer to each other. The combination of different DNA binding proteins such as transcription factors and histones; epigenetic marks such as gene position and dynamic modification of DNA and histones; and the three dimensional organisation of regulatory landscape interact in a pervasive and cell specific manner to generate complex spatiotemporal expression patterns. Chromatin Immunoprecipitation (ChIP seq) and Chromosome Conformation Capture (Hi C and 5C) approaches can be integrated with the whole transcriptome shotgun sequencing (RNA-Seq) to decipher Spatial Pattern of binding of regulatory elements to their target genes.

Détails de l'édition

• Éditeur: LAP LAMBERT Academic Publishing
• Date d'édition: 2017
• Langue: anglais
• ISBN 10: 3330345845
• ISBN 13: 9783330345843
• Reliure: Broché
• Nombre de pages: 60
• Coordonnées du fabricant: non disponible
• Personne responsable: non disponible