Articles liés à Molecular Dynamic Simulation Studies

Molecular Dynamic Simulation Studies - Couverture souple

Bollapalli, Vijay Raj; Morusupalli, V. Raghavendra Rao

 
9783330650909: Molecular Dynamic Simulation Studies
Couverture souple
ISBN 10 : 3330650907 ISBN 13 : 9783330650909
Editeur : Scholars' Press, 2017

Synopsis

Mdm2 has been identified as a p53 interacting protein towards represses p53 transcriptional activity.Mdm2 achieves this repression by binding to P53 and blocking the N- terminal transactivation domain of p53. Mdm2 is a p53 responsive gene that is; its transcription can be activated by p53. When p53 is stabilized, the transcription of Mdm2 is also induced, resulting in higher mdm2 protein levels causing recognition and repair, transcription regulation problems leading to cancer. Thus inhibiting the mdm2- p53 interactions has been proven to be most promising approach for cancer therapy.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Présentation de l'éditeur

Mdm2 has been identified as a p53 interacting protein towards represses p53 transcriptional activity.Mdm2 achieves this repression by binding to P53 and blocking the N- terminal transactivation domain of p53. Mdm2 is a p53 responsive gene that is; its transcription can be activated by p53. When p53 is stabilized, the transcription of Mdm2 is also induced, resulting in higher mdm2 protein levels causing recognition and repair, transcription regulation problems leading to cancer. Thus inhibiting the mdm2- p53 interactions has been proven to be most promising approach for cancer therapy.

Biographie de l'auteur

Dr. VIJAY RAJ. BOLLAPALLIM.Sc.(Biochem),B.Ed.Spl.Edn(HI),M.Ed.spl.Edn(HI), M.Phil(Biochem), PhD (Biotechnology),AV-Therapist, MABAP, FAGE. is an honorary consultant for differently abled persons in hospital administration, and associate director for development action for Women network (Dawn). He possesses distinguish experiences in research.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
Scholars' Press
Date d'édition
2017
Langue
anglais
ISBN 10 
3330650907
ISBN 13 
9783330650909
Reliure
Broché
Nombre de pages
220
Coordonnées du fabricant
non disponible
Personne responsable
non disponible