A comparative evaluation of memory enhancing ability of Ocimum species - Couverture souple

Singh, Varinder; Kahol, Aditi; Shri, Richa

 
9783330652552: A comparative evaluation of memory enhancing ability of Ocimum species
Couverture souple
ISBN 10 : 3330652551 ISBN 13 : 9783330652552
Editeur : Scholars' Press, 2018

Synopsis

Plants are valued greatly as enhancers of cognitive functions. Plants rich in polyphenols hold great promise for management of neurodegenerative diseases. In this study, some common polyphenol-rich Ocimum species i.e. O. basilicum, O. gratissimum and O. sanctum were examined for their anti-amnesic potential. The extracts of the three selected species were examined employing in-vitro tests to determine their antioxidant and acetylcholinesterase capacity. On the basis of in-vitro results, the most active extract was further investigated for the memory enhancing activity using a mouse model of dementia. Ocimum basilicum extract had the highest total phenol content and demonstrated the most significant in-vitro antioxidant and acetylcholinesterase inhibitory potential. In the in-vivo studies, treatment with O. basilicum extract for 7 days improved memory impairment induced by scopolamine in animals along with significant reduction in AChE activity and oxidative stress parameters (reduced TBARS levels and increased GSH activity) in hippocampus and cortex region of brain. This may be developed as a cognition enhancer after detailed testing.

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Présentation de l'éditeur

Plants are valued greatly as enhancers of cognitive functions. Plants rich in polyphenols hold great promise for management of neurodegenerative diseases. In this study, some common polyphenol-rich Ocimum species i.e. O. basilicum, O. gratissimum and O. sanctum were examined for their anti-amnesic potential. The extracts of the three selected species were examined employing in-vitro tests to determine their antioxidant and acetylcholinesterase capacity. On the basis of in-vitro results, the most active extract was further investigated for the memory enhancing activity using a mouse model of dementia. Ocimum basilicum extract had the highest total phenol content and demonstrated the most significant in-vitro antioxidant and acetylcholinesterase inhibitory potential. In the in-vivo studies, treatment with O. basilicum extract for 7 days improved memory impairment induced by scopolamine in animals along with significant reduction in AChE activity and oxidative stress parameters (reduced TBARS levels and increased GSH activity) in hippocampus and cortex region of brain. This may be developed as a cognition enhancer after detailed testing.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
Scholars' Press
Date d'édition
2018
Langue
anglais
ISBN 10 
3330652551
ISBN 13 
9783330652552
Reliure
Broché
Nombre de pages
60
Coordonnées du fabricant
non disponible
Personne responsable
non disponible