DNA Hydroxymethylation in Non-coding Repeat Expansion Disorders - Couverture souple

Esanov, Rustam

 
9783330653122: DNA Hydroxymethylation in Non-coding Repeat Expansion Disorders
Couverture souple
ISBN 10 : 3330653124 ISBN 13 : 9783330653122
Editeur : Scholars' Press, 2017

Synopsis

My research is focused on the repeat expansion disorders, a family of disorders that result from the repetitive microsatellite sequence within the gene. In particular, this thesis investigates two non-coding repeat expansion disorders: C9orf72-associated Amyotrophic Lateral Sclerosis (C9-ALS) and the Fragile X Syndrome (FXS). Our group was the first to report the presence of 5-hydroxymethylcytosine, a novel epigenetic mark and active DNA demethylation intermediate, at the expanded loci of patients with C9-ALS and FXS.

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Présentation de l'éditeur

My research is focused on the repeat expansion disorders, a family of disorders that result from the repetitive microsatellite sequence within the gene. In particular, this thesis investigates two non-coding repeat expansion disorders: C9orf72-associated Amyotrophic Lateral Sclerosis (C9-ALS) and the Fragile X Syndrome (FXS). Our group was the first to report the presence of 5-hydroxymethylcytosine, a novel epigenetic mark and active DNA demethylation intermediate, at the expanded loci of patients with C9-ALS and FXS.

Biographie de l'auteur

Rustam grew up in Ashgabat, Turkmenistan and attended Fatih University in Istanbul, Turkey to study biology. During his PhD at the University of Miami, he characterized novel epigenetic abnormalities associated with the repeat expansion disorders using induced pluripotent stem cells as a disease model.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
Scholars' Press
Date d'édition
2017
Langue
anglais
ISBN 10 
3330653124
ISBN 13 
9783330653122
Reliure
Broché
Nombre de pages
132
Coordonnées du fabricant
non disponible
Personne responsable
non disponible