Early Lactate Clearance as an Independent Predictor of Survival in Patients with Presumed Sepsis - Couverture souple

Patel, Parth

Couverture souple

ISBN 10 : 3346692922 ISBN 13 : 9783346692924

Editeur : Grin Verlag, 2022

Synopsis

Doctoral Thesis / Dissertation from the year 2022 in the subject Medicine - Internal Medicine, grade: 100, language: English, abstract: In the relentless battle against sepsis, where every second counts, can a single biomarker hold the key to unlocking improved survival rates? This groundbreaking research delves into the critical role of early lactate clearance as a predictor of survival in patients battling presumed sepsis, a condition known for its diagnostic and management complexities. This study meticulously examines the relationship between lactate clearance and patient outcomes, challenging existing paradigms and seeking to refine our understanding of this deadly condition. Through a comprehensive review of existing literature on sepsis, lactate metabolism, and prognostic biomarkers, this investigation rigorously analyzes previous studies to identify knowledge gaps and methodological limitations. The study meticulously outlines its design, participant selection criteria, and data collection methods, ensuring transparency and reproducibility. By employing robust statistical analyses, the research uncovers the strength and significance of the correlation between early lactate clearance and survival, presenting key findings in a clear and concise manner, supported by illustrative tables and figures. This dissertation bridges the gap between research and practice by interpreting study results within the context of existing knowledge, exploring implications for diagnosis, management, and prognosis of sepsis, ultimately aiming to improve clinical outcomes and guide future research endeavors in the realm of intensive care and medical research. Discover how this investigation contributes to the evolving landscape of sepsis management, offering valuable insights for healthcare professionals striving to enhance patient care and combat mortality associated with this life-threatening condition. Explore the potential of lactate clearance as an independent predictor of m

A propos du livre

À propos de la quatrième de couverture

Doctoral Thesis / Dissertation from the year 2022 in the subject Medicine - Internal Medicine, grade: 100, , language: English, abstract: This paper tries to answer the research question: Is the early clearance of lactate related to outcome and prognosis of patients of sepsis? The aim of the study comprises measurement of serial serum lactate levels in patients presenting with sepsis and correlating: early lactate clearance with mortality, early lactate clearance versus first (baseline) lactate level in mortality prediction, early lactate clearance versus APACHE II score in mortality prediction and early lactate clearance versus non lactate clearance in mortality prediction. Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection. Clinical organ dysfunction [presumed sepsis] can be represented by an increase in the Sequential [Sepsis-related] APACHE II score of 12 points or more, which is associated with in-hospital mortality greater than 10%. Sepsis is the most common cause of lactic acidosis, and septic patients with lactic acidosis show a higher mortality rate. The etiology of lactic acidosis in sepsis is complex. It may result from either impaired lactate clearance or increased lactate production. Therefore, increased or sustained lactate levels represent severe sepsis or septic shock. Lactate level has also been used as a prognostic indicator for mortality. In particular, the patients with an initial lactate level ¿ 3.0 mmol/L had higher mortality risks, and the probability of death was substantially increased with a high initial lactate level. Some studies reported that lactate clearance, derived from calculating the change in lactate levels at different times, may have potential prognostic value. These studies have proved that a decrease in these markers within the first several hours may be predictive of a favorable outcome. However, no study has yet examined which factor is the most important mortality risk factor among initial lactate, lactate clearance, or inflammatory markers in severe sepsis patients with lactic acidosis. Lactate elevation is an important marker of impaired tissue perfusion in patients with sepsis and is often elevated even in the absence of arterial hypotension. Blood lactate concentrations ¿3 mmol/L are unusual in normal and non critically ill hospitalized patients, regardless of their underlying comorbidities.

Détails de l'édition

• Éditeur: Grin Verlag
• Date d'édition: 2022
• Langue: anglais
• ISBN 10: 3346692922
• ISBN 13: 9783346692924
• Reliure: Broché
• Numéro d'édition: 1
• Nombre de pages: 96
• Coordonnées du fabricant: GRIN Publishing GmbH; info@grin.com; ; Waltherstraße 23; München; 80337; Allemagne