Pharmacokinetics and Metabolism in Drug Design - Couverture rigide

Smith, Dennis A.; Waterbeemd, Han Van De; Walker, Don K.

Couverture rigide

ISBN 10 : 3527301976 ISBN 13 : 9783527301973

Editeur : Wiley-VCH Verlag GmbH, 2001

Synopsis

The medical benefits of a drug are not only dependent on its biological effect, but also on its "life cycle" within the organism - from its absorption into the blood, distribution to tissue until its eventual breakdown or excretion by the liver and kidneys. Here, the authors, all of them employed at Pfizer in the discovery and development of new active substances, discuss the significant parameters and processes important for the absorption, distribution and retention of drug compounds in the body, plus the potential problems created by their transformation into toxic by-products. The authors cover everything from the fundamental principles right up to the latest developments using high throughput methods to analyze the pharmacokinetic properties of active substances. Particular emphasis is placed on the impact of pharmacokinetic parameters on the discovery of new drugs - one of the most challenging tasks in global pharmaceutical research. Thus, this book is aimed at all those dealing professionally with the development and application of pharmaceutical substances. Furthermore, the readily comprehensible style of writing makes it equally suitable for students of pharmacy and related subjects, who feel that pharmacokinetics is covered too briefly in the standard textbooks.

A propos du livre

À propos de l'auteur

The authors are leading scientists in the Drug Metabolism department of Pfizer, one of the top five pharmaceutical companies in the world.

Détails de l'édition

• Éditeur: Wiley-VCH Verlag GmbH
• Date d'édition: 2001
• Langue: anglais
• ISBN 10: 3527301976
• ISBN 13: 9783527301973
• Reliure: Relié
• Nombre de pages: 160
• Coordonnées du fabricant: non disponible
• Personne responsable: non disponible