Drug Bioavailability: Estimation of Solubility, Permeability, Absorption and Bioavailability - Couverture rigide

Waterbeemd, Han Van De; Lennernas, Hans

 
9783527304387: Drug Bioavailability: Estimation of Solubility, Permeability, Absorption and Bioavailability
Couverture rigide
ISBN 10 : 352730438X ISBN 13 : 9783527304387
Editeur : Wiley-VCH Verlag GmbH, 2003

Synopsis

The peroral application (swallowing) of a medicine means that the body must first resorb the active substance before it can begin to take effect. The efficacy of drug uptake depends on the one hand on the chemical characteristics of the active substance, above all on its solubility and membrane permeability. On the other hand, it is determined by the organism's ability to absorb pharmaceuticals by way of specific transport proteins or to excrete them. Since many pharmacologically active substances are poorly suited for oral intake, a decisive criterion for the efficacy of a medicine is its so--called bioavailability. Written by an international team from academia and the pharmaceutical industry, this book covers all aspects of the oral bioavailability of medicines. The focus is placed on methods for determining the parameters relevant to bioavailability. These range from modern physicochemical techniques via biological studies in vitro and in vivo right up to computer--aided predictions. The authors specifically address possibilities for optimizing bioavailability during the early screening stage for the active substance. Its clear structure and comprehensive coverage make this book equally suitable for researchers and lecturers in industry and teaching.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Revue de presse

" this book would make a valuable resource for scientists working in drug discovery and early drug development " ( Pharmaceutical Research, June 2004)

"This monograph is without a doubt the most comprehensive and up to date publication on drug bioavailability available today...very highly recommended..." (Journal of Medicinal Chemistry, Vol. 47, No. 7)

"This is an excellent book, which is very well suited for both teachers and newcomers to the field, who can use it as a starting point for further in–depth studies of the relevant literature. Experienced researchers from different disciplines will get the rapid introduction they desire and learn about the various aspects connected to drug bioavailability."
Sven Grüneberg, Stefan Güssregen, Chemistry, Computational Chemistry, Aventis Pharma Deutschland GmbH, Frankfurt a.M., (Angewandte Chemie and Angewandte Chemie International Edition, 2/04)



" this book would make a valuable resource for scientists working in drug discovery and early drug development " ( Pharmaceutical Research, June 2004)

"This monograph is without a doubt the most comprehensive and up to date publication on drug bioavailability available today...very highly recommended..." (Journal of Medicinal Chemistry, Vol. 47, No. 7)

Présentation de l'éditeur

The peroral application (swallowing) of a medicine means that the body must first resorb the active substance before it can begin to take effect. The efficacy of drug uptake depends on the one hand on the chemical characteristics of the active substance, above all on its solubility and membrane permeability. On the other hand, it is determined by the organism′s ability to absorb pharmaceuticals by way of specific transport proteins or to excrete them. Since many pharmacologically active substances are poorly suited for oral intake, a decisive criterion for the efficacy of a medicine is its so–called bioavailability.

Written by an international team from academia and the pharmaceutical industry, this book covers all aspects of the oral bioavailability of medicines. The focus is placed on methods for determining the parameters relevant to bioavailability. These range from modern physicochemical techniques via biological studies in vitro and in vivo right up to computer–aided predictions. The authors specifically address possibilities for optimizing bioavailability during the early screening stage for the active substance.
Its clear structure and comprehensive coverage make this book equally suitable for researchers and lecturers in industry and teaching.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
Wiley-VCH Verlag GmbH
Date d'édition
2003
Langue
anglais
ISBN 10 
352730438X
ISBN 13 
9783527304387
Reliure
Relié
Nombre de pages
602
Coordonnées du fabricant
non disponible
Personne responsable
non disponible