The Development of the Perineum in the Human: A Comprehensive Histological Study with a Special Reference to the Role of the Stromal Components - Couverture souple

Van Der Putte, S.C. J.

Couverture souple

ISBN 10 : 3540210393 ISBN 13 : 9783540210399

Editeur : Springer Berlin Heidelberg, 2008

Synopsis

References. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 126 Subject Index. . . . . . . . . . . . . . . . . . . . . . . . . . . . 133 1 Introduction The developmental steps which lead to the formation of the human perineum seem firmly established (Arey 1965; Hamilton and Mossman1972; Moore and Persaud 1998; Wartenberg 1993; Sadler 1995; Larsen 1997). They form the base for the evaluation of the pathogenesis of a great variety of complicated and often serious malformations which occur in this region. This concept has, however, been challenged by the results of an investigation into the n- mal and abnormal development of the anorectum in pig (van der Putte and Neeteson 1983, 1984; van der Putte 1986). Observations revealed that at least in pig, a major element in current ideas about the early development of the perineum, namely the process by which the original simple cloaca is sub- vided into a urogenital and anal part is incorrect, while additional obser- tions strongly suggested that the same may be true for ideas about female and male sexual transformation. A preliminary investigation in human - bryos gave similar indications (van der Putte 1986). The data supported e- lier critical findings (Politzer 1931, 1932; Wijnen 1964; Ludwig 1965) which have apparently been ignored, possibly because they seemed to hinder the understanding of the pathogenesis of congenital malformations such as - perforate anus and hypospadias.

Détails de l'édition

• Éditeur: Springer Berlin Heidelberg
• Date d'édition: 2008
• Langue: anglais
• ISBN 10: 3540210393
• ISBN 13: 9783540210399
• Reliure: Broché
• Nombre de pages: 148
• Coordonnées du fabricant: ProductSafety@springernature.com; ProductSafety@springernature.com; ; Poststr. 9; Darmstadt; 64293; Allemagne