Role of Apoptosis in Infection (289) - Couverture rigide

Couverture rigide

ISBN 10 : 3540230068 ISBN 13 : 9783540230069

Editeur : Springer-Verlag Berlin and Heidelberg GmbH & Co. K, 2005

Synopsis

Apoptosis is a regulated, energy-dependent process by which a cell se- destructs. This mechanism of programmed cell death plays an important role in normal development and control of cell numbers in mature a- mals. Apoptosis was initially defined by morphological criteria to describe the distinctive appearance of dying cells that developed nuclear conden- tion, cell shrinkage, and cytoplasmic blebbing. Initiation of the apoptotic process can come from external or internal stimuli and is highly regulated both by molecules that facilitate and by molecules that inhibit the process. Common features of apoptosis include activation of proteases and - cleases, mitochondrial membrane permeabilization, chromatin disruption, and translocation of phosphatidylserine from the inner to the outer s- face of the plasma membrane. Apoptotic cells attract phagocytes that - gulf the apoptotic bodies and prevent tissue damage in the region. Intense investigation of the cell death process has defined many molecular features of the pathway by which regulation and execution can be exploited by pathogens.

A propos du livre

À propos de l'auteur

Diane E. Griffin, Professor, Department Chair, PhD and MD, Stanford University, 1968, Molecular Microbiology and Immunology

Détails de l'édition

• Éditeur: Springer-Verlag Berlin and Heidelberg GmbH & Co. K
• Date d'édition: 2005
• Langue: anglais
• ISBN 10: 3540230068
• ISBN 13: 9783540230069
• Reliure: Relié
• Nombre de pages: 305
• Éditeur: Griffin Diane E.
• Coordonnées du fabricant: Springer Nature Customer Service Center GmbH; ProductSafety@springernature.com; ; Europaplatz 3; Heidelberg; 69115; Allemagne