Signaling Pathways for Translation: Insulin and Nutrients - Couverture rigide

Couverture rigide

ISBN 10 : 3540417095 ISBN 13 : 9783540417095

Editeur : Springer-Verlag Berlin and Heidelberg GmbH & Co. K, 2001

Synopsis

The articles in the present volume are by major contributors to our under- standing of signaling pathways affecting protein synthesis. They focus pri- marily on two extracellular anabolic signals, although others are included as well. Insulin is one of the best-studied extracellular regulators of protein syn- thesis. Several of the known pathways for regulation of protein synthesis were elucidated using insulin-dependent systems. Regulation of protein synthesis by amino acids, by contrast, is an emerging field that has recently received a great deal of attention. The dual role of amino acids as substrates for protein syn- thesis and regulators of the overall process has only recently been recognized. Since amino acids serve as precursors for proteins, one might expect that with- holding an essential amino acid would inhibit the elongation phase. Surpris- ingly, research has shown that it is the initiation phase of protein synthesis that is restricted during amino acid starvation. Understanding the mechanisms by which the biosynthesis of proteins is reg- ulated is important for several reasons. Protein synthesis consumes a major portion of the cellular ATP that is generated. Therefore, small changes in protein synthesis can have great consequences for cellular energy metabolism. Translation is also a major site for control of gene expression, since messenger RNAs differ widely in translational efficiency, and changes to the protein syn- thesis machinery can differentially affect recruitment of individual mRNAs.

Détails de l'édition

• Éditeur: Springer-Verlag Berlin and Heidelberg GmbH & Co. K
• Date d'édition: 2001
• Langue: anglais
• ISBN 10: 3540417095
• ISBN 13: 9783540417095
• Reliure: Relié
• Nombre de pages: 196
• Éditeur: Rhoads Robert E.
• Coordonnées du fabricant: non disponible
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