Pattern Formation in Zebrafish - Couverture rigide

Couverture rigide

ISBN 10 : 354043576X ISBN 13 : 9783540435761

Editeur : Springer-Verlag Berlin and Heidelberg GmbH & Co. K, 2002

Synopsis

What makes an ideal model system to study embryonic development? The answer to this question has varied in the course of scientific quest, depending on the available experimental approaches. Yet, at the beginning of the new millennium, most of the mainstream model organisms have one feature in common, they are amenable to genetic analysis. Indeed, the genetic approach has proven remarkably effective in the dissection of complex biological phenomena, starting with the regulation of the lactose operon in Escherichia coli, the decision between the lysogenic and lytic cycles of the lambda phage and the yeast cell cycle control. The genetic screens for mutations affecting embryonic development of a fruit fly, Drosophila melanogaster, carried out by Christiane Niisslein-Volhard, Eric Wieschaus and Edward Lewis, marked the turning point in experimental approaches to embryonic development of more complex organisms. The resulting mutants facilitated identification of the key regulatory molecules, while their phenotypic classes hinted at the underlying regulatory mechanisms. This work not only provided a paradigm for genetic dissection of other developmental processes, but also inspired many budding embryologists throughout the world. Soon thereafter, George Streisinger noted that, among vertebrates, the zebrafish, Danio rerio, offered many features facilitating the dissection of nervous system development and function. Among these, transparency of the embryo, ease of husbandry, and the highly prolific nature make the zebrafish a good genetic model system.

Détails de l'édition

• Éditeur: Springer-Verlag Berlin and Heidelberg GmbH & Co. K
• Date d'édition: 2002
• Langue: anglais
• ISBN 10: 354043576X
• ISBN 13: 9783540435761
• Reliure: Relié
• Nombre de pages: 438
• Éditeur: Solnica-Krezel Lilianna
• Coordonnées du fabricant: non disponible
• Personne responsable: CMN Printpool Inh. Mathis Neumann; https://www.also.com/ec/cms5/en_6000/6000/index.jsp; ; Friedrich-Karl-Str. 9; Hamburg; Allemagne