Mitochondrial Dysfunction and Oxidative Damage in Neurodegenerative Diseases - Couverture rigide

Couverture rigide

ISBN 10 : 3540588779 ISBN 13 : 9783540588771

Editeur : Springer-Verlag Berlin and Heidelberg GmbH & Co. K, 1995

Synopsis

This volume explores the role of defects in oxidative phosphorylation and oxidative stress in the pathogenesis of neurodegenerative diseases. It describes the relationship between impaired energy metabolism, excytotoxicity and the generation of free radicals. The role of mitochondrial dysfunction in normal aging, and its potential role in the delayed onset of neurodegenerative diseases, as well as the result of animal studies using mitochondrial toxins such as MPTP and 3-nitropropionic acid, are described. The evidence for both dysfunction and oxidative stress in Alzheimer's disease, Parkinson's disease, Huntington's disease and amyotrophic lateral sclerosis are critically reviewed. Lastly, five different therapeutic approaches to the treatment of neurodegenerative diseases are discussed.

Détails de l'édition

• Éditeur: Springer-Verlag Berlin and Heidelberg GmbH & Co. K
• Date d'édition: 1995
• Langue: anglais
• ISBN 10: 3540588779
• ISBN 13: 9783540588771
• Reliure: Relié
• Nombre de pages: 136
• Éditeur: Beal M. Flint
• Coordonnées du fabricant: non disponible
• Personne responsable: non disponible