Articles liés à Tubulin-Binding Agents: Synthetic, Structural and Mechanisti...

Tubulin-Binding Agents: Synthetic, Structural and Mechanistic Insights - Couverture rigide

Livre 2 sur 84: Topics in Current Chemistry
 
9783540690368: Tubulin-Binding Agents: Synthetic, Structural and Mechanistic Insights
Couverture rigide
ISBN 10 : 3540690360 ISBN 13 : 9783540690368
Editeur : Springer-Verlag Berlin and Heidelberg GmbH & Co. K, 2009

Synopsis

reviews. The SAR data are discussed in light of the structural information available for each agent. The second chapter focuses on the total synthesis of the marine sponge-derived polyketide discodermolide. A comprehensive survey of the synthetic chemistry efforts of several groups over a 14-year period is provided together with a compa- son of the different approaches. The third chapter describes a comprehensive study of the mechanisms of activity of microtubules stabilizing drugs. Thermodynamic, kinetic, structural and fu- tional data on microtubules stabilizing drugs are discussed in an interdisciplinary manner to generate a "time-resolved" picture of the interaction of the drugs with different tubulin forms. The fourth and fifth chapters review the efforts and achievements made in the characterization of the structure of the complexes of tubulin with microtubules stabilizing agents by NMR (Chapter 4) and EM (Chapter 5). Especially evident is the discrepancy of the results obtained for epothilones, where the two techniques deliver radically different structures of the bound drug. Both NMR and EM models are, however, able to explain a consistent set of SAR data. The authors of the two chapters discuss critically the advantages and limitations of each methodology.

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Présentation de l'éditeur

This series presents critical reviews of the present position and future trends in modern chemical research. It contains short and concise reports on chemistry, each written by the world renowned experts.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
Springer-Verlag Berlin and Heidelberg GmbH & Co. K
Date d'édition
2009
Langue
anglais
ISBN 10 
3540690360
ISBN 13 
9783540690368
Reliure
Relié
Numéro d'édition
1
Nombre de pages
342
Éditeur
Carlomagno Teresa
Coordonnées du fabricant
non disponible
Personne responsable
CMN Printpool Inh. Mathis Neumann
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