Oncogenes Meet Metabolism: From Deregulated Genes to a Broader Understanding of Tumour Physiology - Couverture rigide

Couverture rigide

ISBN 10 : 3540794778 ISBN 13 : 9783540794776

Editeur : Springer-Verlag Berlin and Heidelberg GmbH & Co. K, 2008

Synopsis

In 1920s, Otto Warburg described the phenomenon of 'aerobic glycolysis', the ability of tumour cells to convert glucose to lactate in the presence of normal oxygen conditions. Warburg's hypothesis of an altered metabolism in cancer cells found no immediate acceptance, though it was latter confirmed for most human tumours. With the advent of molecular biology the focus in tumour research has shifted towards the search for oncogenes. However, the interest in cancer molecular profiling eventually led to a renaissance of the Warburg effect trying to combine genetic alterations with effects on metabolism with the help of modern analytic technologies to rapidly analyze broad varieties of metabolites in various tissues and bodyfluids (metabonomics).

Détails de l'édition

• Éditeur: Springer-Verlag Berlin and Heidelberg GmbH & Co. K
• Date d'édition: 2008
• Langue: anglais
• ISBN 10: 3540794778
• ISBN 13: 9783540794776
• Reliure: Relié
• Nombre de pages: 265
• Éditeur: Kroemer Guido, Mumberg Dominik, Keun Kector, Riefke Björn, Steger-Hartmann Thomas, Petersen Kirstin
• Coordonnées du fabricant: non disponible
• Personne responsable: CMN Printpool Inh. Mathis Neumann; https://www.also.com/ec/cms5/en_6000/6000/index.jsp; ; Friedrich-Karl-Str. 9; Hamburg; Allemagne