Gene Selection Based on Consistency Modelling, Algorithms and Applications: Genetic Algorithm Application in Bioinformatics Data Analysis - Couverture souple

Hu, Yingjie

 
9783639008838: Gene Selection Based on Consistency Modelling, Algorithms and Applications: Genetic Algorithm Application in Bioinformatics Data Analysis
Couverture souple
ISBN 10 : 3639008839 ISBN 13 : 9783639008838
Editeur : VDM Verlag Dr. Müller, 2008

Synopsis

Consistency modeling for gene selection is a new topic emerging from recent cancer bioinformatics research. The result of classification or clustering on a training set was often found very different from the same operations on a testing set. Here, the issue is addressed as a consistency problem. In practice, the inconsistency of microarray datasets prevents many typical gene selection methods working properly for cancer diagnosis and prognosis. In an attempt to deal with this problem, a new concept of performance-based consistency is proposed in this thesis. The proposed consistency concept has been investigated on eight benchmark microarray and proteomic datasets. The experimental results show that the different microarray datasets have different consistency characteristics, and that better consistency can lead to an unbiased and reproducible outcome with good disease prediction accuracy.

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Éditeur
VDM Verlag Dr. Müller
Date d'édition
2008
Langue
anglais
ISBN 10 
3639008839
ISBN 13 
9783639008838
Reliure
Broché
Nombre de pages
112
Coordonnées du fabricant
non disponible
Personne responsable
non disponible