Impact of Folate Absorption and Transport for Nutrition and Drug Targeting - Couverture souple

Ceren Alemdaroglu, N.

 
9783639010688: Impact of Folate Absorption and Transport for Nutrition and Drug Targeting
Couverture souple
ISBN 10 : 363901068X ISBN 13 : 9783639010688
Editeur : VDM Verlag Dr. Müller, 2008

Synopsis

Food-drug interactions play an important role in the alteration of the pharmacokinetics as well as pharmacodynamics of drugs in vivo. The interaction of folic acid and tea was observed at the level of cellular uptake using Caco-2 cell monolayers. Remarkably, the clinical study with healthy human volunteers confirmed the interaction between tea and folic acid in vivo leading to lower bioavailabilities of folic acid. This outcome addresses the clinical consequences of folate deficiency caused by high intakes of tea. Folates have been employed as targeting moieties to tumor cells. Folic acid has a high affinity to folate receptors which are overexpressed in tumor cells. Therefore internalization of folic acid conjugated drugs or drug delivery systems are readily carried out via those receptors. A novel micelle platform consisting of amphiphilic DNA block copolymers was introduced for the first time for chemotherapeutic drug delivery, allowing the combinatorial testing of the drug carrier system. Folic acid conjugated nanoparticles act as a potential chemotherapeutic drug delivery system in in vitro assays.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Présentation de l'éditeur

Food-drug interactions play an important role in the alteration of the pharmacokinetics as well as pharmacodynamics of drugs in vivo. The interaction of folic acid and tea was observed at the level of cellular uptake using Caco-2 cell monolayers. Remarkably, the clinical study with healthy human volunteers confirmed the interaction between tea and folic acid in vivo leading to lower bioavailabilities of folic acid. This outcome addresses the clinical consequences of folate deficiency caused by high intakes of tea. Folates have been employed as targeting moieties to tumor cells. Folic acid has a high affinity to folate receptors which are overexpressed in tumor cells. Therefore internalization of folic acid conjugated drugs or drug delivery systems are readily carried out via those receptors. A novel micelle platform consisting of amphiphilic DNA block copolymers was introduced for the first time for chemotherapeutic drug delivery, allowing the combinatorial testing of the drug carrier system. Folic acid conjugated nanoparticles act as a potential chemotherapeutic drug delivery system in in vitro assays.

Biographie de l'auteur

The author was born in Ankara, 1979; obtained BS & MS degrees from Gazi University, School of Pharmacy; specialization in the field of Pharmaceutical Technology; awarded a DAAD scholarship and completed her PhD at the University of Mainz in the Institute of Pharmaceutical Technology&Biopharmacy.Currently, a scientist at the University of Münster.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
VDM Verlag Dr. Müller
Date d'édition
2008
Langue
anglais
ISBN 10 
363901068X
ISBN 13 
9783639010688
Reliure
Broché
Nombre de pages
228
Coordonnées du fabricant
non disponible
Personne responsable
non disponible