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Protein Dynamics: A Study of the Model-free Analysis of NMR Relaxation Data - Couverture souple

D''Auvergne, Edward

 
9783639057621: Protein Dynamics: A Study of the Model-free Analysis of NMR Relaxation Data
Couverture souple
ISBN 10 : 3639057627 ISBN 13 : 9783639057621
Editeur : VDM Verlag Dr. Müller, 2008

Synopsis

Functionally, proteins are the most important building blocks of life. Their diverse biological activities are often intricately linked to their internal mobility. Model-free analysis of NMR relaxation data is the most widely employed method for experimentally studying protein dynamics at the atomic level. This book investigates all aspects of the model-free data analysis chain, and shows how to obtain a much improved dynamic description of macromolecules. Using statistical model selection the choice of model-free model is overhauled to uncover previously hidden motions, failed model-free models are eliminated, the optimisation of the model-free models is significantly improved to increase the accuracy of the final results and a new protocol is presented for the optimisation of the global model which reverses the current logic thereby solving the hidden motion problem and the issues of artificial chemical exchange and artificial nanosecond motions. The advances presented here should be of interest to anyone studying the internal motions of complex molecules.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Présentation de l'éditeur

Functionally, proteins are the most important building blocks of life. Their diverse biological activities are often intricately linked to their internal mobility. Model-free analysis of NMR relaxation data is the most widely employed method for experimentally studying protein dynamics at the atomic level. This book investigates all aspects of the model-free data analysis chain, and shows how to obtain a much improved dynamic description of macromolecules. Using statistical model selection the choice of model-free model is overhauled to uncover previously hidden motions, failed model-free models are eliminated, the optimisation of the model-free models is significantly improved to increase the accuracy of the final results and a new protocol is presented for the optimisation of the global model which reverses the current logic thereby solving the hidden motion problem and the issues of artificial chemical exchange and artificial nanosecond motions. The advances presented here should be of interest to anyone studying the internal motions of complex molecules.

Biographie de l'auteur

Edward J. d''Auvergne, PhD: Studied science, majoring in biochemistry, at the University of Melbourne. Postdoctoral researcher at the Max Planck Institute for Biophysical Chemistry, Göttingen.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
VDM Verlag Dr. Müller
Date d'édition
2008
Langue
anglais
ISBN 10 
3639057627
ISBN 13 
9783639057621
Reliure
Broché
Nombre de pages
360
Coordonnées du fabricant
non disponible
Personne responsable
non disponible