Deformable Microparticles With Multiple Functions for Drug Delivery - Couverture souple

Thula, Taili

 
9783639074956: Deformable Microparticles With Multiple Functions for Drug Delivery
Couverture souple
ISBN 10 : 3639074955 ISBN 13 : 9783639074956
Editeur : VDM Verlag Dr. Mueller E.K., 2008

Synopsis

Since the HIV epidemic of the 1990s, researchers have attempted to develop a red blood cell analog. Even though some of these substitutes are now in Phase III of clinical trials, their use is limited by side effects and short half-life in the human body. As a result, there is still a need for an effective erythrocyte analog with minimum immunogenic and side effects, so that it can be used for multiple applications. Finding new approaches to develop more efficient blood substitutes will not only bring valuable advances in the clinical approach, but also in the area of in vitro testing of medical devices. This work examined the feasibility of creating a deformable multi-functional, biodegradable, biocompatible particle for applications in drug delivery and device testing. As a preliminary evaluation, different types of microcapsules were synthesized using natural and synthetic polymers, various cross-linking agents, and diverse manufacturing techniques. After fully characterizing of each system, the most promising red blood cell analog in terms of deformability, stability and toxicity was determined.

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Éditeur
VDM Verlag Dr. Mueller E.K.
Date d'édition
2008
Langue
anglais
ISBN 10 
3639074955
ISBN 13 
9783639074956
Reliure
Broché
Nombre de pages
132
Coordonnées du fabricant
non disponible
Personne responsable
non disponible