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Biodegradable in Situ Microparticles for Sustained Protein Delivery - Couverture souple

Körber, Martin

 
9783639076592: Biodegradable in Situ Microparticles for Sustained Protein Delivery

Synopsis

The objective of this work was to evaluate the suitability of in situ forming biodegradable microparticles for the controlled delivery of proteins. Particular goals were: a) to evaluate the flexibility of the release patterns of in situ implant and in situ microparticle formulations using hen egg white lysozyme as model protein; b) to characterize, if and how the integrity of the model protein is affected by formulation ingredients, the manufacturing process, sto-rage of the ISM and the release from the formulations; c) to optimize protein delivery from in situ forming implant and microparticle systems, with regard to shape and completeness of the release; d) to find / validate reliable methods allowing to extract and thus to characterize the model protein in biodegradable in situ formulations.

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