Application of Solid-state Kinetics to Desolvation Reactions - Couverture souple

Khawam, Ammar

 
9783639091144: Application of Solid-state Kinetics to Desolvation Reactions
Couverture souple
ISBN 10 : 3639091140 ISBN 13 : 9783639091144
Editeur : VDM Verlag, 2008

Synopsis

The book presents an overview of the solid-state kinetic literature in-cluding methodologies used, mathematical derivations and pharma-ceutical applications. The book investigates the relationship between calculation methods and artifactual results observed in solid-state kinetics. A new approach is proposed for evaluating solid-state kinetic data, this approach combines modelistic and model-free methods in a complimentary manner to achieve consistent kinetic results. Experimental data focused on studying the solid-state stability of several structurally related solvates of sulfameter (5-methoxysulfadiazine), this was done by studying the kinetics of their desolvation reaction both isothermally and nonisothermally. Calculated kinetic parameters were compared and related to the crystal structure of these solvates. A relationship was established between desolvation kinetic parameters (e.g., activation energy) and the solvent size. The solid-state reaction models selected also corresponded to the single crystal structure of the sulfameter-solvate system.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Éditeur
VDM Verlag
Date d'édition
2008
Langue
anglais
ISBN 10 
3639091140
ISBN 13 
9783639091144
Reliure
Broché
Nombre de pages
356
Coordonnées du fabricant
non disponible
Personne responsable
non disponible