Gamma-Secretase and Its Substrates: A Bioinformatics Approach - Couverture souple

Nan, Fei

 
9783639102123: Gamma-Secretase and Its Substrates: A Bioinformatics Approach
Couverture souple
ISBN 10 : 3639102126 ISBN 13 : 9783639102123
Editeur : VDM Verlag Dr. Müller, 2008

Synopsis

Gamma-secretase is an enzymatic complex critical to amyloid formation and other important pathophysiological processes. Non-specific gamma-secretase inhibitors are not ideal for intervention of familial Alzheimer¿s disease. Also gamma-secretase cleaves a variety of substrates. But different sites are cleaved even in a single substrate and no consensus sequence for cleavage by gamma-secretase is identified. We hypothesize that consensus compositional sequence in components of gamma-secretase and its substrates should exist during gamma-secretase regulation and specific gammasecretase inhibitor based on such consensus sequence may act as a therapeutic intervention for familial Alzheimer¿s disease. There are two stages in our research. First, We find the candidates by the methods of bioinformatics. Then, we use the traditional biological methods to verify the critical role of the candidates including the protein purification, recognition, and functional domain interaction. The book can serve as reference for computational biology-oriented professionals in advanced research development.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Présentation de l'éditeur

Gamma-secretase is an enzymatic complex critical to amyloid formation and other important pathophysiological processes. Non-specific gamma-secretase inhibitors are not ideal for intervention of familial Alzheimer¿s disease. Also gamma-secretase cleaves a variety of substrates. But different sites are cleaved even in a single substrate and no consensus sequence for cleavage by gamma-secretase is identified. We hypothesize that consensus compositional sequence in components of gamma-secretase and its substrates should exist during gamma-secretase regulation and specific gammasecretase inhibitor based on such consensus sequence may act as a therapeutic intervention for familial Alzheimer¿s disease. There are two stages in our research. First, We find the candidates by the methods of bioinformatics. Then, we use the traditional biological methods to verify the critical role of the candidates including the protein purification, recognition, and functional domain interaction. The book can serve as reference for computational biology-oriented professionals in advanced research development.

Biographie de l'auteur

Ph.D.: Computer Science at West Virginia University (2008), M.S.: Microbiology and Immunology at West Virginia University (2008), B.Eng.: Computer Science at Northeastern University (2002). Member of Sigma Xi, IEEE and ACM. Software Engineer at Microsoft Corporation, Redmond, Washington.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
VDM Verlag Dr. Müller
Date d'édition
2008
Langue
anglais
ISBN 10 
3639102126
ISBN 13 
9783639102123
Reliure
Broché
Nombre de pages
72
Coordonnées du fabricant
non disponible
Personne responsable
non disponible