Comparative Analysis of Biological Networks: Algorithmic and Analytical Methods for Cross-Species Analysis of Biomolecular Interactions - Couverture souple

Koyutürk, Mehmet

 
9783639110357: Comparative Analysis of Biological Networks: Algorithmic and Analytical Methods for Cross-Species Analysis of Biomolecular Interactions
Couverture souple
ISBN 10 : 3639110358 ISBN 13 : 9783639110357
Editeur : VDM Verlag Dr. Müller, 2009

Synopsis

Recent developments in molecular biology have resulted in experimental data that entails the relationships and interactions between biomolecules. Biomolecular interaction data, generally referred to as biological or cellular networks, are frequently abstracted using graph models. In systems biology, comparative analysis of these networks provides understanding of functional modularity in the cell by integrating cellular organization, functional hierarchy, and evolutionary conservation. In this study, we address a number of algorithmic issues associated with comparative analysis of molecular interaction networks. We first discuss the problem of identifying common sub-networks in a collection of molecular interaction networks belonging to diverse species. With a view to understanding the conservation and divergence of functional modules, we also develop network alignment techniques, grounded in theoretical models of network evolution. Finally, we probabilistically analyze the existence of highly connected and conserved subgraphs in random graphs, in order to assess the statistical significance of the patterns identified by our algorithms.

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Présentation de l'éditeur

Recent developments in molecular biology have resulted in experimental data that entails the relationships and interactions between biomolecules. Biomolecular interaction data, generally referred to as biological or cellular networks, are frequently abstracted using graph models. In systems biology, comparative analysis of these networks provides understanding of functional modularity in the cell by integrating cellular organization, functional hierarchy, and evolutionary conservation. In this study, we address a number of algorithmic issues associated with comparative analysis of molecular interaction networks. We first discuss the problem of identifying common sub-networks in a collection of molecular interaction networks belonging to diverse species. With a view to understanding the conservation and divergence of functional modules, we also develop network alignment techniques, grounded in theoretical models of network evolution. Finally, we probabilistically analyze the existence of highly connected and conserved subgraphs in random graphs, in order to assess the statistical significance of the patterns identified by our algorithms.

Biographie de l'auteur

Mehmet Koyutürk received his M.S. degree in Computer Engineering (1998) and Ph.D. degree Computer Science (2006), respectively from Bilkent University and Purdue University. In 2007, he joined the Electrical Engineering & Computer Science Department of Case Western Reserve University as T. & D. Schroeder Assistant Professor.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
VDM Verlag Dr. Müller
Date d'édition
2009
Langue
anglais
ISBN 10 
3639110358
ISBN 13 
9783639110357
Reliure
Broché
Nombre de pages
136
Coordonnées du fabricant
non disponible
Personne responsable
non disponible