Advances in computational protein design: Development of more efficient search algorithms and their application to the full-sequence design of larger proteins - Couverture souple

Hom, Geoffrey

 
9783639127010: Advances in computational protein design: Development of more efficient search algorithms and their application to the full-sequence design of larger proteins

Synopsis

Protein design is the art of choosing an amino acid sequence that will fold into a desired structure. Computational protein design aims to quantify and automate this process. In computational protein design, various metrics may be used to calculate an energy score for a sequence with respect to a desired protein structure. An ongoing challenge is to find the lowest-energy sequences from amongst the vast multitude of sequence possibilities. A variety of exact and approximate algorithms may be used in this search.

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Présentation de l'éditeur

Protein design is the art of choosing an amino acid sequence that will fold into a desired structure. Computational protein design aims to quantify and automate this process. In computational protein design, various metrics may be used to calculate an energy score for a sequence with respect to a desired protein structure. An ongoing challenge is to find the lowest-energy sequences from amongst the vast multitude of sequence possibilities. A variety of exact and approximate algorithms may be used in this search.

Biographie de l'auteur

Geoffrey Hom grew up in California. After completing his Ph.D., Geoff did a postdoc studying the genetics of the disease lupus. Geoff is currently exploring computer programming, with an emphasis on non-profit educational software developed in ActionScript 3.0.

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