Evolution of multiple alignments: Towards efficient data exploitation and knowledge extraction in the genomic era - Couverture souple

Thompson, Julie Dawn

 
9783639169324: Evolution of multiple alignments: Towards efficient data exploitation and knowledge extraction in the genomic era
Couverture souple
ISBN 10 : 3639169328 ISBN 13 : 9783639169324
Editeur : VDM Verlag, 2009

Synopsis

Genomics and proteomics technologies have led to a paradigm shift in bioinformatics, where the traditional reductionist approach is replaced by a more global, integrated view. In this context, multiple sequence alignments provide an ideal environment for the reliable integration of information from a complete genome to a gene and its related products. In this work, the sequence analysis field is reviewed and three example developments are described: (i) a benchmark for the objective evaluation of multiple alignment algorithms, (ii) a multiple alignment ontology (MAO) for nucleic acid or protein sequences and structures, (iii) an information management system (MACSIMS) that exploits the multiple alignment and the organisation provided by the ontology. The work is central to bioinformatics today and should be particularly useful to researchers working in various fields, such as genome analysis, target characterisation for structural proteomics, the study of human genetic pathologies, or the development of new drug discovery strategies.

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Éditeur
VDM Verlag
Date d'édition
2009
Langue
anglais
ISBN 10 
3639169328
ISBN 13 
9783639169324
Reliure
Broché
Nombre de pages
168
Coordonnées du fabricant
non disponible
Personne responsable
non disponible