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Characterization of Hyperpolarized Xe-129 NMR Spectra: Characterization of Hyperpolarized Xe-129 Dissolved in Perfluorooctyl Bromide Emulsions as a Novel Magnetic Resonance Contrast Agent - Couverture souple

Gherase, Mihai

 
9783639170375: Characterization of Hyperpolarized Xe-129 NMR Spectra: Characterization of Hyperpolarized Xe-129 Dissolved in Perfluorooctyl Bromide Emulsions as a Novel Magnetic Resonance Contrast Agent
Couverture souple
ISBN 10 : 3639170377 ISBN 13 : 9783639170375
Editeur : VDM Verlag, 2009

Synopsis

This book describes the modeling and experimental effort in trying to use hyperpolarized Xe-129 (H-Xe) dissolved in Perfluorooctyl Bromide (PFOB) emulsions as an Nuclear Magnetic Resonance (NMR) contrast agent for cancer detection. H-Xe dissolved in PFOB emulsions stabilized with egg-yolk phospholipid (EYP) has been suggested as a possible in vivo NMR contrast agent. A two-compartment radial diffusive exchange model based on the generalized Bloch equations was developed. The model was used to investigate the NMR spectra of H-Xe dissolved in PFOB emulsions. The permeability of the EYP membrane was estimated by fitting the linewidths of the experimental NMR spectra with the modeled spectra linewidths. The experiments also showed that the linewidths of the NMR spectra of H-Xe in PFOB emulsions depend on the PFOB concentration because of the H-Xe diffusive exchange. Bulk water flow measurements were demonstrated by dynamic acquisition of H-Xe NMR spectra while the bolus formed of H-Xe gas in PFOB emulsions diluted during the passage through a coil.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Présentation de l'éditeur

This book describes the modeling and experimental effort in trying to use hyperpolarized Xe-129 (H-Xe) dissolved in Perfluorooctyl Bromide (PFOB) emulsions as an Nuclear Magnetic Resonance (NMR) contrast agent for cancer detection. H-Xe dissolved in PFOB emulsions stabilized with egg-yolk phospholipid (EYP) has been suggested as a possible in vivo NMR contrast agent. A two-compartment radial diffusive exchange model based on the generalized Bloch equations was developed. The model was used to investigate the NMR spectra of H-Xe dissolved in PFOB emulsions. The permeability of the EYP membrane was estimated by fitting the linewidths of the experimental NMR spectra with the modeled spectra linewidths. The experiments also showed that the linewidths of the NMR spectra of H-Xe in PFOB emulsions depend on the PFOB concentration because of the H-Xe diffusive exchange. Bulk water flow measurements were demonstrated by dynamic acquisition of H-Xe NMR spectra while the bolus formed of H-Xe gas in PFOB emulsions diluted during the passage through a coil.

Biographie de l'auteur

The author has received a Ph.D. in Physics with specialization in Medical Physics from Carleton University in Ottawa, Canada. Currently, he is a Postdoctoral Fellow in the field of X-ray Fluorescence applications in medicine at Mount Allison University in Sackville, Canada.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
VDM Verlag
Date d'édition
2009
Langue
anglais
ISBN 10 
3639170377
ISBN 13 
9783639170375
Reliure
Broché
Nombre de pages
100
Coordonnées du fabricant
non disponible
Personne responsable
non disponible