Articles liés à AN IN VITRO GENOTOXICITY STUDY OF VALUE ADDED HYDROXYAPATITE...

AN IN VITRO GENOTOXICITY STUDY OF VALUE ADDED HYDROXYAPATITE: A BONE REPLACEMENT MATERIAL - Couverture souple

Akram, Hassan

 
9783639189094: AN IN VITRO GENOTOXICITY STUDY OF VALUE ADDED HYDROXYAPATITE: A BONE REPLACEMENT MATERIAL
Couverture souple
ISBN 10 : 3639189094 ISBN 13 : 9783639189094
Editeur : VDM Verlag, 2009

Synopsis

Hydroxyapatite(HA) used for bone replacement is one of the most active areas of biomaterials research currently.It has been used for the last 30 years due to its excellent biocompatibility,osseoconduction and osseointegration.Many modifications have been done to develop a stronger,tougher and biocompatible HA due to pure HA is brittle.Our scientists have made this value added HA that is less brittle compared to pure HA.This study was to evaluate the genotoxicity of the value added HA using Bacterial Reverse Mutation Assay/Ames test.Mutated Salmonella typhimurium and Escherichia coli strains were chosen for this test. The results of the tests revealed that all strains showed no reserve mutation with the tested HA at all concentrations.In conclusion,the tested HA was considered to have no reverse mutagenic potential. Ultimately researchers and scientists should concern the needs of biocompatibility testing of new materials before allowing for medical use,mutagenesis systems to exclude cytotoxic or mutagenic properties are applied worldwide.This book,therefore,provokes them to undergo genotoxicity studies particularly on implant materials.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Présentation de l'éditeur

Hydroxyapatite(HA) used for bone replacement is one of the most active areas of biomaterials research currently.It has been used for the last 30 years due to its excellent biocompatibility,osseoconduction and osseointegration.Many modifications have been done to develop a stronger,tougher and biocompatible HA due to pure HA is brittle.Our scientists have made this value added HA that is less brittle compared to pure HA.This study was to evaluate the genotoxicity of the value added HA using Bacterial Reverse Mutation Assay/Ames test.Mutated Salmonella typhimurium and Escherichia coli strains were chosen for this test. The results of the tests revealed that all strains showed no reserve mutation with the tested HA at all concentrations.In conclusion,the tested HA was considered to have no reverse mutagenic potential. Ultimately researchers and scientists should concern the needs of biocompatibility testing of new materials before allowing for medical use,mutagenesis systems to exclude cytotoxic or mutagenic properties are applied worldwide.This book,therefore,provokes them to undergo genotoxicity studies particularly on implant materials.

Biographie de l'auteur

BDS, M.Clin.Dent.Restorative(Periodontology). Senior Lecturer and Co-ordinator of Periodontics, School of Dental Sciences, Universiti Sains Malaysia (USM). Consultant Periodontist, Hospital Universiti Sains Malaysia (HUSM). Researcher in the field of biomaterials and genotoxicity testing.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
VDM Verlag
Date d'édition
2009
Langue
anglais
ISBN 10 
3639189094
ISBN 13 
9783639189094
Reliure
Broché
Nombre de pages
88
Coordonnées du fabricant
non disponible
Personne responsable
non disponible