Adenovirus Receptor Interactions: Structural Basis of Adenovirus Attachment to its Receptor CD46 - Couverture souple

Persson, David

 
9783639189841: Adenovirus Receptor Interactions: Structural Basis of Adenovirus Attachment to its Receptor CD46
Couverture souple
ISBN 10 : 3639189841 ISBN 13 : 9783639189841
Editeur : VDM Verlag, 2009

Synopsis

Adenoviruses are common human pathogens causing a number of infectious diseases. They have been found in virtually all organs, producing symptoms ranging from the common cold to pneumonia. Additionally, they also cause a variety of clinical symptoms such as epidemic keratoconjunctivitis, pharyngoconjunctival fever, infantile gastroenteritis, cystitis and urinary tract infections. Individuals with a poorly functioning immune systems are especially prone to severe life-threatening infections. In 1977 Philip Sharp and Richard Roberts discovered the ability of Adenoviruses to split genes, and were in 1993 awarded the Nobel Prize in Physiology and Medicine for their discovery. Today, Adenoviruses are mostly studied for the ability to be used as delivery vehicles in gene therapy. We here studied Adenoviruses binding to the cellular receptor CD46, characterizing the binding mechanism at an atomic level. We used a combination of biological and biochemical methods connecting structure and function to define the Adenovirus interaction with CD46. Our work will have implications for drug design, focusing on reducing Adenovirus complications during organ transplantation.

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Présentation de l'éditeur

Adenoviruses are common human pathogens causing a number of infectious diseases. They have been found in virtually all organs, producing symptoms ranging from the common cold to pneumonia. Additionally, they also cause a variety of clinical symptoms such as epidemic keratoconjunctivitis, pharyngoconjunctival fever, infantile gastroenteritis, cystitis and urinary tract infections. Individuals with a poorly functioning immune systems are especially prone to severe life-threatening infections. In 1977 Philip Sharp and Richard Roberts discovered the ability of Adenoviruses to split genes, and were in 1993 awarded the Nobel Prize in Physiology and Medicine for their discovery. Today, Adenoviruses are mostly studied for the ability to be used as delivery vehicles in gene therapy. We here studied Adenoviruses binding to the cellular receptor CD46, characterizing the binding mechanism at an atomic level. We used a combination of biological and biochemical methods connecting structure and function to define the Adenovirus interaction with CD46. Our work will have implications for drug design, focusing on reducing Adenovirus complications during organ transplantation.

Biographie de l'auteur

B. David Persson, Bachelorn in Biochemistry at the University of Umea 2003, Masters in Molecular Biology at the University of Umea 2004, PhD in Structure Biology at the University of Tuebingen 2008.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
VDM Verlag
Date d'édition
2009
Langue
anglais
ISBN 10 
3639189841
ISBN 13 
9783639189841
Reliure
Broché
Nombre de pages
148
Coordonnées du fabricant
non disponible
Personne responsable
non disponible