Applications of Polyvalent Carbohydrate Display on Viral Particles: Lessons in Nanotechnology - Couverture souple

Kaltgrad, Eiton

 
9783639201659: Applications of Polyvalent Carbohydrate Display on Viral Particles: Lessons in Nanotechnology
Couverture souple
ISBN 10 : 3639201655 ISBN 13 : 9783639201659
Editeur : VDM Verlag, 2009

Synopsis

Nanotechnology focuses on the miniaturization of tools for various biomedical applications such as drug delivery and cell targeting. Virus particles are ideal scaffolds to build the tools for such applications. Viruses offer boundless possibilities for chemical and genetic manipulation, contributing various shapes and sizes for scientists to harness. Chemical conjugation of carbohydrates to virus capsids allows for the engineering of cell interactions. Here, we describe the use of two virus particles for studies of these interactions. Glycoconjugates of Cowpea Mosaic Virus (CPMV) display strong binding to carbohydrate receptors and act as effective immunogens for the production of anti-carbohydrate antibodies related to various tumors. Furthermore, enzymatic synthesis of polysaccharides directly on the surface of CPMV offers facile construction and purification of cell targeting viruses. Glycoconjugates of bacteriophage QB also demonstrate high affinity for carbohydrate receptors and remarkable affinity for a carbohydrate specific anti-HIV monoclonal antibody. Chemists and biologists will find this work valuable as a guide to the many uses of viruses in nanotechnology.

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À propos de l?auteur

Eiton Kaltgrad received his B.S. in Biology from the University of California at San Diego and his Ph.D. in Chemical Biology from The Scripps Research Institute in 2007. Currently, he is a scientist at Calmune Corp. M.G. Finn received his B.S. in Chemistry from Caltech and his Ph.D. in Chemistry from MIT. Currently, he is a Professor at TSRI.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
VDM Verlag
Date d'édition
2009
Langue
anglais
ISBN 10 
3639201655
ISBN 13 
9783639201659
Reliure
Broché
Nombre de pages
180
Coordonnées du fabricant
non disponible
Personne responsable
non disponible