Role of Matrix Metalloproteinases in Tissue Remodeling: relevance to pathogenesis of restenosis, aortic aneurism, joint and disc degeneration research - Couverture souple

Margolin M.D., Ph.D., Leon

Couverture souple

ISBN 10 : 3639207890 ISBN 13 : 9783639207897

Editeur : VDM Verlag Dr. Müller, 2009

Synopsis

Matrix metalloproteinases (MMP) are the key enzymes in the pathogenesis of osteoarthritis and inflammatory arthritis. This study was performed on the rat common carotid artery model. This model has better accessibility and reliable injury assessment techniques in comparison to articular cartilage. This groundbreaking study shows that MMP inhibition resulted in a significant decrease in the cell proliferation and the remodeling of the extracellular matrix up to 2½ months after the MMP injection versus untreated control group and that these effects were associated with a marked reduction in MMP-2 activity. We strongly advocate testing of non hydroxamate type matrix metalloproteinase inhibitors in larger animals and in the clinical setting for degenerative joint and disc disease. Dr. Margolin's "out of the box" thinking, original study design and sharp indepth analysis are a new important step in restenosis, aortic aneurism and metastasis research as well in developing a disease modifying agent for degenerative disc and joint disease.

Détails de l'édition

• Éditeur: VDM Verlag Dr. Müller
• Date d'édition: 2009
• Langue: anglais
• ISBN 10: 3639207890
• ISBN 13: 9783639207897
• Reliure: Broché
• Nombre de pages: 88
• Coordonnées du fabricant: non disponible
• Personne responsable: non disponible