Growth Factor VN Complexes Accelerate the Healing of Diabetic Ulcers - Couverture souple

Noble, Anthony

Couverture souple

ISBN 10 : 3639216202 ISBN 13 : 9783639216202

Editeur : VDM Verlag Dr. Müller, 2010

Synopsis

The findings outlined in this thesis show that VN:IGFBP:IGF-I complexes can elicit enhanced growth and migration in cells derived from skin from both normal and diabetic patients. Further, these responses are maintained in conditions found in the diabetic wound microenvironment, namely in the presence of high glucose and high calcium. Together these findings demonstrate the potential of the VN:IGFBP:IGF complexes as wound healing agents to treat wounds, especially diabetic ulcers. Such delayed healing wounds represent a significant burden to healthcare systems and are one of the primary conditions that leads to the amputation of limbs. Current treatments do not address the co-ordination of ECM and growth factor action on cells that is here demonstrated to stimulate multiple wound healing related functional effects in skin cells. The data presented here represents important new information that may guide the design of new integrated therapeutics which may enhance the healing of recalcitrant diabetic ulcers.

Détails de l'édition

• Éditeur: VDM Verlag Dr. Müller
• Date d'édition: 2010
• Langue: anglais
• ISBN 10: 3639216202
• ISBN 13: 9783639216202
• Reliure: Broché
• Nombre de pages: 248
• Coordonnées du fabricant: non disponible
• Personne responsable: non disponible