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Oral Cancer: An Update on Prognostic Factors: p53 and p63 immunoexpression and the HPV role in oral squamous cell carcinoma - Couverture souple

Oliveira, Lucinei Roberto; Zucoloto, Sérgio; Ribeiro-Silva, Alfredo

 
9783639232790: Oral Cancer: An Update on Prognostic Factors: p53 and p63 immunoexpression and the HPV role in oral squamous cell carcinoma
Couverture souple
ISBN 10 : 3639232798 ISBN 13 : 9783639232790
Editeur : VDM Verlag Dr. Müller, 2010

Synopsis

Brazil is among the countries with the largest indexes of oral squamous cell carcinoma (OSCC). The role of p53 and p63 in the OSCC prognosis is still debatable. The involvement of the human papilomavirus (HPV) in CEO is still another factor no elucidated. Our study aimed to evaluate the patients with OSCC diagnosed in the Teaching Hospital of the Ribeirao Preto Medical School of the Sao Paulo University, as well as to investigate the relationship between the p53 and p63 proteins immunoexpression and the HPV presence with some relevant clinicopathological parameters to the tumor prognostic. The clinical data were obtained from the medical files of 424 patients. One hundred twenty-six patients were selected for the survival study, 106 for the immunohistochemical investigation, 45 for the IHQ analysis with matched samples (MS), and 87 for the polymerase chain reaction test of HPV and multivariate analysis. Significant differences related to the OSCC prognostic were found in multivariate analysis for age, tumoral site and p53. A HPV association to oral carcinogenesis was verified in the non-smoker patients.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Présentation de l'éditeur

Brazil is among the countries with the largest indexes of oral squamous cell carcinoma (OSCC). The role of p53 and p63 in the OSCC prognosis is still debatable. The involvement of the human papilomavirus (HPV) in CEO is still another factor no elucidated. Our study aimed to evaluate the patients with OSCC diagnosed in the Teaching Hospital of the Ribeirao Preto Medical School of the Sao Paulo University, as well as to investigate the relationship between the p53 and p63 proteins immunoexpression and the HPV presence with some relevant clinicopathological parameters to the tumor prognostic. The clinical data were obtained from the medical files of 424 patients. One hundred twenty-six patients were selected for the survival study, 106 for the immunohistochemical investigation, 45 for the IHQ analysis with matched samples (MS), and 87 for the polymerase chain reaction test of HPV and multivariate analysis. Significant differences related to the OSCC prognostic were found in multivariate analysis for age, tumoral site and p53. A HPV association to oral carcinogenesis was verified in the non-smoker patients.

Biographie de l'auteur

Formal Education-Dentistry/Ribeirao Preto Dentistry School/University of Sao Paulo(USP). MSc.Oral Medicine-Piracicaba Dentistry School/UNICAMP. Periodontology (Lato Sensu Specialization)-Dentistry Research Center Sao Leopoldo Mandic. PhD and Postdoctoral Fellowship in Pathology-Department of Pathology, Ribeirao Preto Medical School/USP.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
VDM Verlag Dr. Müller
Date d'édition
2010
Langue
anglais
ISBN 10 
3639232798
ISBN 13 
9783639232790
Reliure
Broché
Nombre de pages
72
Coordonnées du fabricant
non disponible
Personne responsable
non disponible