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THYROID GLAND AND CHROMIUM TOXICITY: "Effect of Hexavalent Chromium administration on Hypothalamic-Pituitary-Thyroid axis in Rat" - Couverture souple

Mahmood, Tariq; Zia Qureshi, Irfan

 
9783639256611: THYROID GLAND AND CHROMIUM TOXICITY: "Effect of Hexavalent Chromium administration on Hypothalamic-Pituitary-Thyroid axis in Rat"
Couverture souple
ISBN 10 : 3639256611 ISBN 13 : 9783639256611
Editeur : VDM Verlag Dr. Müller, 2010

Synopsis

Toxicity due to heavy metals is of major concern in Pakistan. Mercury, cadmium, chromium, arsenic, lead, zinc and copper concentrations have increased to alarming levels in the water, soil and air which have become large dumps of industrial effluents. Physiologically, heavy metals can profoundly affect the functioning of the endocrine system and in Pakistan, thyroid related diseases are also very common. Chromium in hexavalent form is highly toxic and a known carcinogen, however as opposed to the trivalent form, its toxic effects on the thyroid structure and function are relatively unexplored. Acute exposure to chromium (VI) can occur in the occupational set up. The present study, therefore, investigated the thyroid gland structure and function following intraperitoneal administration of potassium dichromate (Cr-VI) in laboratory rats.Diverse techniques were employed during the study. The results give an insight to the toxic effects of hexavalent chromium on the thyroid gland and describe how the metal interferes with the functioning of the gland; not only with its morphology but also at cellular and molecular levels.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Présentation de l'éditeur

Toxicity due to heavy metals is of major concern in Pakistan. Mercury, cadmium, chromium, arsenic, lead, zinc and copper concentrations have increased to alarming levels in the water, soil and air which have become large dumps of industrial effluents. Physiologically, heavy metals can profoundly affect the functioning of the endocrine system and in Pakistan, thyroid related diseases are also very common. Chromium in hexavalent form is highly toxic and a known carcinogen, however as opposed to the trivalent form, its toxic effects on the thyroid structure and function are relatively unexplored. Acute exposure to chromium (VI) can occur in the occupational set up. The present study, therefore, investigated the thyroid gland structure and function following intraperitoneal administration of potassium dichromate (Cr-VI) in laboratory rats.Diverse techniques were employed during the study. The results give an insight to the toxic effects of hexavalent chromium on the thyroid gland and describe how the metal interferes with the functioning of the gland; not only with its morphology but also at cellular and molecular levels.

Biographie de l'auteur

Dr.Tariq Mahmood joined the department of Wildlife Management PMAS Arid Agriculture University Rawalpindi as an Assistant Professor in May 2007. He was awarded the degree of PhD in the field of Animal Sciences from Quaid-I-Azam University Islamabad in March 2009. He is currently conducting research work on small and medium sized mammals.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
VDM Verlag Dr. Müller
Date d'édition
2010
Langue
anglais
ISBN 10 
3639256611
ISBN 13 
9783639256611
Reliure
Broché
Nombre de pages
132
Coordonnées du fabricant
non disponible
Personne responsable
non disponible