Regulation of B Cell Migration and Antigen Receptor Signaling By Lsc: Regulation of Lsc Activity and Role in B Cell Migration and Antigen Receptor Signaling - Couverture souple

Hu, Jiancheng

 
9783639274721: Regulation of B Cell Migration and Antigen Receptor Signaling By Lsc: Regulation of Lsc Activity and Role in B Cell Migration and Antigen Receptor Signaling
Couverture souple
ISBN 10 : 3639274725 ISBN 13 : 9783639274721
Editeur : VDM Verlag Dr. Müller, 2010

Synopsis

Cell migration is accomplished by chemoattractant receptors signaling the spatially-restricted activation of rho gtpases. specifically, chemoattractant receptors signal via gai and downstream guanine nucleotide exchange factors (gefs), p-rex and pixa, to activate rac and cdc42 at the leading edge and ultimately leads to cellular protrusion. In contrast, chemoattractant receptor signaling by ga12/13 activate rhoa at the trailing edge and promote cytoskeletal contraction. however, the gef(s) that activate rhoa downstream of chemoattractant receptor and ga12/13 have not been identified. here our study showed that: (1) the activity of lsc is controlled by oligomerization, (2) lsc is a key rhogef that functions as an effector of ga12/13-associated chemoattractant receptors to activate rhoa at the trailing edge and regulate the release of integrin-mediated cell adhesion during cell migration. Besides controlling cell migration, chemoattractant receptor signaling has also been suggested to regulate lymphocyte antigen receptor signaling. our study further revealed that bcr signaling is regulated by lysophosphatidic acid, and the underlying molecular mechanisms of this regulation.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Présentation de l'éditeur

Cell migration is accomplished by chemoattractant receptors signaling the spatially-restricted activation of rho gtpases. specifically, chemoattractant receptors signal via gai and downstream guanine nucleotide exchange factors (gefs), p-rex and pixa, to activate rac and cdc42 at the leading edge and ultimately leads to cellular protrusion. In contrast, chemoattractant receptor signaling by ga12/13 activate rhoa at the trailing edge and promote cytoskeletal contraction. however, the gef(s) that activate rhoa downstream of chemoattractant receptor and ga12/13 have not been identified. here our study showed that: (1) the activity of lsc is controlled by oligomerization, (2) lsc is a key rhogef that functions as an effector of ga12/13-associated chemoattractant receptors to activate rhoa at the trailing edge and regulate the release of integrin-mediated cell adhesion during cell migration. Besides controlling cell migration, chemoattractant receptor signaling has also been suggested to regulate lymphocyte antigen receptor signaling. our study further revealed that bcr signaling is regulated by lysophosphatidic acid, and the underlying molecular mechanisms of this regulation.

Biographie de l'auteur

Jiancheng Hu is Postdoc Fellow, since 2007, Washington University at St. Louis and Howard Hughes Medical Institute (St. Louis, USA) 2001-2007, PhD, University of Colorado Health Sciences Center (Denver, USA) 1998-2001, MS, Peking University (Beijing, P.R. China) 1992-1996, BS, East China University of Science and Technology (Shanghai, P.R. China)

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
VDM Verlag Dr. Müller
Date d'édition
2010
Langue
anglais
ISBN 10 
3639274725
ISBN 13 
9783639274721
Reliure
Broché
Nombre de pages
136
Coordonnées du fabricant
non disponible
Personne responsable
non disponible