Viral Docking Protein Targeted Dapsone Delivery to Nerve Endings: From Conventional to Novel - Couverture souple

Sogani, Manish; Singh Jadon, Rajesh; P. Vyas, Suresh

 
9783639295283: Viral Docking Protein Targeted Dapsone Delivery to Nerve Endings: From Conventional to Novel
Couverture souple
ISBN 10 : 3639295285 ISBN 13 : 9783639295283
Editeur : VDM Verlag Dr. Müller, 2010

Synopsis

Leprosy is a neuropathic disease caused by the M.laprae, which specially affect the nerves of the dermal tissue and multiply here. Conventional treatment is based on antibiotics and essentially Dapsone, which is the core drug for all leprosy treatment. Leprosy requires high doses of Dapsone for very long period of time, which in turn, is responsible for the side effect. Such prolonged therapy, with untoward side effects, is a major draw back. Thus it is desirable to make a dosage form, which could avoid most of the adverse effect of Dapsone, and preparing the liposome of the drug can do it. But only drug bearing liposomes don't have the targeting ability. To make liposomes targetable, liposomes are coated with the viral or bacterial docking proteins of bacterial or synthetic origin, which are simply the bacterial or viral proteins that make the attachment of bacteria/virus to the specific cell receptors for the fusion with cell membrane and causing invasion into the cell. In the case of leprosy a liposome based system could be developed and targeted to nerve endings where the bacterial load is high where they proliferate in tissue specific manner.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Présentation de l'éditeur

Leprosy is a neuropathic disease caused by the M.laprae, which specially affect the nerves of the dermal tissue and multiply here. Conventional treatment is based on antibiotics and essentially Dapsone, which is the core drug for all leprosy treatment. Leprosy requires high doses of Dapsone for very long period of time, which in turn, is responsible for the side effect. Such prolonged therapy, with untoward side effects, is a major draw back. Thus it is desirable to make a dosage form, which could avoid most of the adverse effect of Dapsone, and preparing the liposome of the drug can do it. But only drug bearing liposomes don't have the targeting ability. To make liposomes targetable, liposomes are coated with the viral or bacterial docking proteins of bacterial or synthetic origin, which are simply the bacterial or viral proteins that make the attachment of bacteria/virus to the specific cell receptors for the fusion with cell membrane and causing invasion into the cell. In the case of leprosy a liposome based system could be developed and targeted to nerve endings where the bacterial load is high where they proliferate in tissue specific manner.

Biographie de l'auteur

Manish Sogani Earned his M.pharm from Dr. HS Gour University, Sagar INDIA. Currently he is working as research officer in sun pharmaceutical industries limited, Badoda, India, for the formulation development and technology transfer for Injections, depot injection and new drug delivery systems.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
VDM Verlag Dr. Müller
Date d'édition
2010
Langue
anglais
ISBN 10 
3639295285
ISBN 13 
9783639295283
Reliure
Broché
Nombre de pages
156
Coordonnées du fabricant
non disponible
Personne responsable
non disponible