The Influence of Leukemia Inhibitory Factor on Cardiomyogenesis: Implications for Stem Cell-Based Therapy of the Diseased Heart - Couverture souple

Wiedner, Marc

 
9783639301830: The Influence of Leukemia Inhibitory Factor on Cardiomyogenesis: Implications for Stem Cell-Based Therapy of the Diseased Heart
Couverture souple
ISBN 10 : 3639301838 ISBN 13 : 9783639301830
Editeur : VDM Verlag Dr. Müller, 2010

Synopsis

Heart failure represents one of the leading causes of death in western civilization and is primarily the result of previous myocardial infarction. The fact that cardiac tissue is unable to regenerate after infarction led to the general belief that the heart of mammalian species is a terminally differentiated organ. Recently, however, evidence has emerged that the adult heart contains myocardial cells possessing stem cell-like properties, which may have the potential to repair damaged tissue. The identification of factors which could activate these quiescent cardiac stem cells and cause them to differentiate into functional cardiomyocytes would be an important step towards finding new therapies for the treatment of heart diseases. The experiments conducted in this study reveal that leukemia inhibitory factor (LIF) can be utilized as a factor to trigger expansion of cardiac stem cells and induce differentiation into functional heart cells in vitro, which may ultimately prove useful for cell therapy of the diseased heart.

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Éditeur
VDM Verlag Dr. Müller
Date d'édition
2010
Langue
anglais
ISBN 10 
3639301838
ISBN 13 
9783639301830
Reliure
Broché
Nombre de pages
104
Coordonnées du fabricant
non disponible
Personne responsable
non disponible