Articles liés à Protein-Protein Interactions: A tool kit to puzzle...

Protein-Protein Interactions: A tool kit to puzzle out functional networks - Couverture souple

Bellucci, Matteo

 
9783639311600: Protein-Protein Interactions: A tool kit to puzzle out functional networks
Couverture souple
ISBN 10 : 3639311604 ISBN 13 : 9783639311600
Editeur : VDM Verlag Dr. Müller, 2010

Synopsis

Protein-protein interactions regulate signaling pathways within and between cells. They constitute the basis of the quaternary structure of multimeric proteins and represent one of the highest levels of structural organization in biology. Experimental techniques have provided atomic details of many protein-protein complexes. However, although it is feasible to extract common determinants of protein recognition from structural data, recent studies reported an extreme diversity of interaction modes. This is particularly true for transient associations that could be strengthen or weakened by specific cellular conditions, acting as an efficient regulatory mechanism. Here protein-protein interactions are classified and recurrent structural features of molecular recognition are illustrated. Moreover, metal-mediated associations are discussed to exemplify the role of cofactors in the stabilization of transient protein assemblies. In this view, the protein machinery mediating the activation of the nickel-enzyme urease from H. pylori is described. In particular, the activity of the metallo-chaperone UreE is analyzed in depth with respect to the association with its cognate UreG.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

À propos de l'auteur

Born in 1982 in Sassocorvaro, Italy. He achieved his Bachelor (2004) and M.S. Degree (2006) in Molecular and Industrial Biotechnology at the University of Bologna. He obtained his PhD in Biological, Biomedical and Biotechnological Science in April 2010. At present, he is a Junior Postdoc at Centre for Genomic Regulation (CRG) in Barcelona, Spain.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
VDM Verlag Dr. Müller
Date d'édition
2010
Langue
anglais
ISBN 10 
3639311604
ISBN 13 
9783639311600
Reliure
Broché
Nombre de pages
144
Coordonnées du fabricant
non disponible
Personne responsable
non disponible