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A MULTIVALENT LIGAND DISPLAY SYSTEM WITH PLANT VIRUSES: A NOVEL APPROACH TOWARDS STUDYING SPATIAL EFFECTS OF CELL ADHESION - Couverture souple

Lee, Lim

 
9783639314724: A MULTIVALENT LIGAND DISPLAY SYSTEM WITH PLANT VIRUSES: A NOVEL APPROACH TOWARDS STUDYING SPATIAL EFFECTS OF CELL ADHESION
Couverture souple
ISBN 10 : 3639314727 ISBN 13 : 9783639314724
Editeur : VDM Verlag Dr. Müller, 2010

Synopsis

A display platform with viruses containing cell binding sequences can be utilized to study how these ligands with nanoscale ordering can affect cell adhesion, spreading and mesenchymal stem cell differentiation. Previous studies have largely relied on polymeric display systems with clusters of ligands to probe cellular response, but the spatial resolution of polymeric display is limited due to its heterogeneity. The virus display system, being a monodispersed particle, is an ideal tool that allows for superior nanometer scale control. Our findings with the virus-display system reveal that ligand clusters spaced with 2-3 nanometers result in cellular morphological changes, starting from adhesion to spreading, as well as cell differentiation. These results suggest that clusters of ligands on the viruses induce different cellular activities by activating a cluster of the receptors versus a single ligand/receptor event. These cellular events could lead to new insights to some of the fundamental questions in cell differentiation, tumorigenesis and tissue/organ development.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Présentation de l'éditeur

A display platform with viruses containing cell binding sequences can be utilized to study how these ligands with nanoscale ordering can affect cell adhesion, spreading and mesenchymal stem cell differentiation. Previous studies have largely relied on polymeric display systems with clusters of ligands to probe cellular response, but the spatial resolution of polymeric display is limited due to its heterogeneity. The virus display system, being a monodispersed particle, is an ideal tool that allows for superior nanometer scale control. Our findings with the virus-display system reveal that ligand clusters spaced with 2-3 nanometers result in cellular morphological changes, starting from adhesion to spreading, as well as cell differentiation. These results suggest that clusters of ligands on the viruses induce different cellular activities by activating a cluster of the receptors versus a single ligand/receptor event. These cellular events could lead to new insights to some of the fundamental questions in cell differentiation, tumorigenesis and tissue/organ development.

Biographie de l'auteur

Lim Lee was born in South Korea and grew up in southern California. He attended University of California, San Diego for Bachelor of Science in Animal Physiology and Neuroscience. He obtained his doctoral degree in Chemistry at University of South Carolina with emphasis on use of viruses as nanoscale materials.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
VDM Verlag Dr. Müller
Date d'édition
2010
Langue
anglais
ISBN 10 
3639314727
ISBN 13 
9783639314724
Reliure
Broché
Nombre de pages
180
Coordonnées du fabricant
non disponible
Personne responsable
non disponible

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Couverture souple