Synopsis
AMD is the main cause of registered blindness in the Western World and despite recent advances, there is very limited treatment. Transplantation of RPE under the macula represents a potential treatment. We investigated methods to establish an intact functioning RPE monolayer on an artificial substrate that could eventually be implanted under the macula and substitute for damaged native Bruch's membrane. Biomaterials polydimethylsiloxane (PDMS) and expanded polytetrafluoroethylene (ePTFE) are already used widely clinically. Cells, however, do not attach to PDMS and ePTFE. The aim of this study was to investigate the possibility of modifying the surface properties of both substrates to promote the growth and function of healthy RPE monolayers. Works presented here form the thesis completed for a PhD by Dr Y Krishna, under the supervision of Dr C Sheridan, Dr R Williams, Mr D Kent and Professor I Grierson at Eye and Vision Science, University of Liverpool, UK. Studies presented here would be of particular interest to researchers in the field of cell biology, transplant, biomaterials and ocular pathology; as well as medical and surgical retinal specialists.
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ARTIFICIAL SUBSTRATES FOR RETINAL PIGMENT EPITHELIAL (RPE) CELL GROWTH
Edité par
VDM Verlag Dr. Müller, 2011
ISBN 10 : 3639356195
ISBN 13 : 9783639356199
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Etat : New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Autor/Autorin: Krishna YaminiDr Yamini Krishna, MBChB (Hons), MSc, PhD: Graduated in Medicine and Postgraduate degrees from the University of Liverpool. Currently an Ophthalmologist in training in the Mersey Rotation, U.K.AMD is the main ca. N° de réf. du vendeur 151384231
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ARTIFICIAL SUBSTRATES FOR RETINAL PIGMENT EPITHELIAL (RPE) CELL GROWTH | USE OF NONDEGRADABLE SYNTHETIC SUBSTRATES FOR RPE CELL GROWTH, FUNCTION AND TRANSPLANTATION AS A POSSIBLE TREATMENT FOR AGE-RELATED MACULAR DEGENERATION
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Taschenbuch. Etat : Neu. ARTIFICIAL SUBSTRATES FOR RETINAL PIGMENT EPITHELIAL (RPE) CELL GROWTH | USE OF NONDEGRADABLE SYNTHETIC SUBSTRATES FOR RPE CELL GROWTH, FUNCTION AND TRANSPLANTATION AS A POSSIBLE TREATMENT FOR AGE-RELATED MACULAR DEGENERATION | Yamini Krishna | Taschenbuch | Englisch | VDM Verlag Dr. Müller | EAN 9783639356199 | Verantwortliche Person für die EU: preigu GmbH & Co. KG, Lengericher Landstr. 19, 49078 Osnabrück, mail[at]preigu[dot]de | Anbieter: preigu. N° de réf. du vendeur 112046848
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Krishna, Y: ARTIFICIAL SUBSTRATES FOR RETINAL PIGMENT EPITHE
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Taschenbuch. Etat : Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - AMD is the main cause of registered blindness in the Western World and despite recent advances, there is very limited treatment. Transplantation of RPE under the macula represents a potential treatment. We investigated methods to establish an intact functioning RPE monolayer on an artificial substrate that could eventually be implanted under the macula and substitute for damaged native Bruch's membrane. Biomaterials polydimethylsiloxane (PDMS) and expanded polytetrafluoroethylene (ePTFE) are already used widely clinically. Cells, however, do not attach to PDMS and ePTFE. The aim of this study was to investigate the possibility of modifying the surface properties of both substrates to promote the growth and function of healthy RPE monolayers. Works presented here form the thesis completed for a PhD by Dr Y Krishna, under the supervision of Dr C Sheridan, Dr R Williams, Mr D Kent and Professor I Grierson at Eye and Vision Science, University of Liverpool, UK. Studies presented here would be of particular interest to researchers in the field of cell biology, transplant, biomaterials and ocular pathology; as well as medical and surgical retinal specialists. N° de réf. du vendeur 9783639356199
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