Analysis of Protein-Protein Interactions: A Computational Approach - Couverture souple

Ansari, Sam

9783639414677: Analysis of Protein-Protein Interactions: A Computational Approach

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ISBN 10 : 3639414675 ISBN 13 : 9783639414677

Editeur : AV Akademikerverlag, 2012

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Revision with unchanged content. In the past years protein-protein interactions have gained a strong interest in the fields of pharmacy, medicine, biology, and bioinformatics. In this book, statistical information on protein-protein interactions are computationally collec�ted and analyzed. Characteristic properties are determined and their predictability estimated. Therefore, the results from a common docking approach are re-evaluated with the collected information to discriminate structures with high yet biologically meaningless geometric complementarity at the interface region from the near native structures. The results show that although there is a noticeable improvement in the predictability after applying statistical information, the overall accuracy is still low. To find other more specific properties, transient and permanent complexes were compared to each other. The lack of data led to an extensive search for more suitable structural data and the development of an extensive database. This database was ultimately used to retrieve a large number of protein properties that were automatically analyzed for their separation precision. A high accuracy was obtained in separating transient and permanent interactions based on the combination of only four properties. Combining this information with common docking approaches based on geometrical complementarity may lead to satisfying sensitivities.

Biographie de l'auteur

Dr. rer. Nat.:PhD at the Center for Bioinformatics of the Saarland University in Saarbr�cken, Germany. Dipl.-Biol. at the Johann Wolfgang Goethe University in Frankfurt am Main, Germany, with strong focus on genetics, microbiology, and computer science.

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�diteur: AV Akademikerverlag
Date d'�dition: 2012
Langue: anglais
ISBN 10: 3639414675
ISBN 13: 9783639414677
Reliure: Broch�
Nombre de pages: 164
Coordonn�es du fabricant: non disponible
Personne responsable: non disponible

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9783836423090: Analysis of Protein-protein Interactions: A Computational Approach

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ISBN 10 : 383642309X ISBN 13 : 9783836423090
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Analysis of Protein-Protein Interactions

Sam Ansari

Edit� par AV Akademikerverlag Mai 2012, 2012

ISBN 10 : 3639414675 ISBN 13 : 9783639414677

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Taschenbuch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Revision with unchanged content. In the past years protein-protein interactions have gained a strong interest in the fields of pharmacy, medicine, biology, and bioinformatics. In this book, statistical information on protein-protein interactions are computationally collec ted and analyzed. Characteristic properties are determined and their predictability estimated. Therefore, the results from a common docking approach are re-evaluated with the collected information to discriminate structures with high yet biologically meaningless geometric complementarity at the interface region from the near native structures. The results show that although there is a noticeable improvement in the predictability after applying statistical information, the overall accuracy is still low. To find other more specific properties, transient and permanent complexes were compared to each other. The lack of data led to an extensive search for more suitable structural data and the development of an extensive database. This database was ultimately used to retrieve a large number of protein properties that were automatically analyzed for their separation precision. A high accuracy was obtained in separating transient and permanent interactions based on the combination of only four properties. Combining this information with common docking approaches based on geometrical complementarity may lead to satisfying sensitivities. 164 pp. Englisch. N� de r�f. du vendeur 9783639414677

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Analysis of Protein-Protein Interactions

Sam Ansari

Edit� par AV Akademikerverlag, 2012

ISBN 10 : 3639414675 ISBN 13 : 9783639414677

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Etat : New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Autor/Autorin: Ansari SamDr. rer. Nat.:PhD at the Center for Bioinformatics of the Saarland University in Saarbruecken, Germany. Dipl.-Biol. at the Johann Wolfgang Goethe University in Frankfurt am Main, Germany, with strong focus on genetics, micro. N� de r�f. du vendeur 4985683

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Analysis of Protein-Protein Interactions

Sam Ansari

Edit� par AV Akademikerverlag Mai 2012, 2012

ISBN 10 : 3639414675 ISBN 13 : 9783639414677

Neuf Taschenbuch

impression � la demande

Vendeur : buchversandmimpf2000, Emtmannsberg, BAYE, Allemagne

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Taschenbuch. Etat : Neu. This item is printed on demand - Print on Demand Titel. Neuware -Revision with unchanged content. In the past years protein-protein interactions have gained a strong interest in the fields of pharmacy, medicine, biology, and bioinformatics. In this book, statistical information on protein-protein interactions are computationally collected and analyzed. Characteristic properties are determined and their predictability estimated. Therefore, the results from a common docking approach are re-evaluated with the collected information to discriminate structures with high yet biologically meaningless geometric complementarity at the interface region from the near native structures. The results show that although there is a noticeable improvement in the predictability after applying statistical information, the overall accuracy is still low. To find other more specific properties, transient and permanent complexes were compared to each other. The lack of data led to an extensive search for more suitable structural data and the development of an extensive database. This database was ultimately used to retrieve a large number of protein properties that were automatically analyzed for their separation precision. A high accuracy was obtained in separating transient and permanent interactions based on the combination of only four properties. Combining this information with common docking approaches based on geometrical complementarity may lead to satisfying sensitivities.VDM Verlag, Dudweiler Landstra�e 99, 66123 Saarbr�cken 164 pp. Englisch. N� de r�f. du vendeur 9783639414677

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Analysis of Protein-Protein Interactions : A Computational Approach

Sam Ansari

Edit� par AV Akademikerverlag, 2012

ISBN 10 : 3639414675 ISBN 13 : 9783639414677

Neuf Taschenbuch

impression � la demande

Vendeur : AHA-BUCH GmbH, Einbeck, Allemagne

�valuation du vendeur 5 sur 5 �toiles

Taschenbuch. Etat : Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - Revision with unchanged content. In the past years protein-protein interactions have gained a strong interest in the fields of pharmacy, medicine, biology, and bioinformatics. In this book, statistical information on protein-protein interactions are computationally collec ted and analyzed. Characteristic properties are determined and their predictability estimated. Therefore, the results from a common docking approach are re-evaluated with the collected information to discriminate structures with high yet biologically meaningless geometric complementarity at the interface region from the near native structures. The results show that although there is a noticeable improvement in the predictability after applying statistical information, the overall accuracy is still low. To find other more specific properties, transient and permanent complexes were compared to each other. The lack of data led to an extensive search for more suitable structural data and the development of an extensive database. This database was ultimately used to retrieve a large number of protein properties that were automatically analyzed for their separation precision. A high accuracy was obtained in separating transient and permanent interactions based on the combination of only four properties. Combining this information with common docking approaches based on geometrical complementarity may lead to satisfying sensitivities. N� de r�f. du vendeur 9783639414677

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