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Tissue Engineered Scaffolds for Nerve Regeneration: Gradients of Molecules Enhance Nerve Regeneration - Couverture souple

Dodla, Mahesh Chandra

 
9783639433883: Tissue Engineered Scaffolds for Nerve Regeneration: Gradients of Molecules Enhance Nerve Regeneration
Couverture souple
ISBN 10 : 3639433882 ISBN 13 : 9783639433883
Editeur : AV Akademikerverlag, 2012

Synopsis

Revision with unchanged content. Injuries to the nervous system result in severe loss of motor and sensory functions. Nerve autografts are widely used clinically to repair injured nerves. However, nerve grafts have many limitations, including availability and loss of function at donor site. To overcome these problems, we have used a tissue engineering approach to design three-dimensional (3D) scaffolds containing laminin-1 (LN-1) and nerve growth factor (NGF). After nerve injury and during embryonic development, several extra-cellular matrix molecules and neurotrophic factors contribute to nerve regeneration and repair. Our 3D agarose hydrogel scaffolds with gradients of LN-1 and NGF are designed to mimic these in vivo conditions to promote nerve regeneration in rats. These scaffolds have shown to promote nerve regeneration comparable to using nerve autografts in rats. This book, therefore, provides a novel technique of nerve scaffold preparation for greater success in nerve regeneration. Scientists and students of neural engineering could use this technique to design novel scaffolds. Optimization of this technique could result in a viable alternative to using nerve grafts for nerve regeneration.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Présentation de l'éditeur

Revision with unchanged content. Injuries to the nervous system result in severe loss of motor and sensory functions. Nerve autografts are widely used clinically to repair injured nerves. However, nerve grafts have many limitations, including availability and loss of function at donor site. To overcome these problems, we have used a tissue engineering approach to design three-dimensional (3D) scaffolds containing laminin-1 (LN-1) and nerve growth factor (NGF). After nerve injury and during embryonic development, several extra-cellular matrix molecules and neurotrophic factors contribute to nerve regeneration and repair. Our 3D agarose hydrogel scaffolds with gradients of LN-1 and NGF are designed to mimic these in vivo conditions to promote nerve regeneration in rats. These scaffolds have shown to promote nerve regeneration comparable to using nerve autografts in rats. This book, therefore, provides a novel technique of nerve scaffold preparation for greater success in nerve regeneration. Scientists and students of neural engineering could use this technique to design novel scaffolds. Optimization of this technique could result in a viable alternative to using nerve grafts for nerve regeneration.

Biographie de l'auteur

post-doctoral associate at University of Georgia,U.S.A. He received his Bachelors degree inBiotechnology at Indian Institute of Technology,India, and his Doctoral degree in BiomedicalEngineering at Georgia Institute of Technology,U.S.A. He is currently working on using Stem celltechnology for nerve repair.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
AV Akademikerverlag
Date d'édition
2012
Langue
anglais
ISBN 10 
3639433882
ISBN 13 
9783639433883
Reliure
Broché
Nombre de pages
164
Coordonnées du fabricant
non disponible
Personne responsable
non disponible